中文摘要：

目的探讨γ-干扰素释放试验对颈淋巴结结核的辅助诊断价值。方法2014年12月-2016年4月在新疆维吾尔自治区人民医院收治的94例颈淋巴结肿大患者依据病理及细菌学诊断分为颈淋巴结结核病组（52例）及非颈淋巴结结核病组（42例），所有患者均接受了外周血γ-干扰素释放试验，比较两组斑点形成细胞个数（SFCs）。结果颈淋巴结结核病组SFCs中位数（90个）显著高于非颈淋巴结结核病组SFCs中位数（0个），两组差异有统计学意义（P〈0．05）。外周血γ-千扰素释放试验的灵敏度为92．31％（48／52），特异度为69．05％（29／42），阳性预测值为78．69％，阴性预测值为87．88％。结论在结核高负担地区，不能单纯依据外周血γ-千扰素释放试验对颈淋巴结结核做出诊断。

英文摘要：

Objective To evaluate the performance of interferon-γ release assay （IGRAs） in patients with suspected cervical tuberculous lymphadenitis. Methods From December 2014 to April 2016, 94 patients with abnormal cervical lymph node in People＇s Hospital of Xinjiang Uygur Autonomous Region were categorized into cervical tuberculous lymphadenitis group （52 cases） and nonactive cervical tuberculous lymphadenitis group （42 cases） according to histopatho- logic and microbiological findings. IGRAs using peripheral blood mononuclear cells was performed to examine the IFN-γ response to the Mycobacterium tuberculosis-specific antigens. The number of cells （SFCs） in two groups was compared. Results SFCs median in cervical tuberculous lymphadenitis group （90） was significantly higher than that in non-cervical tuberculous lymphadenitis group （0）, the difference was statistically significant （P 〈 0.05）. The sensitivity of peripheral blood gamma-interferon release assay was 92.31% （48/52）, the specificity was 69.05% （29/42）, the positive predictive value was 78.69%, the negative predictive value was 87.88%. Conclusion In a high tuberculosis burden setting, results of IGRAs are of limited value in the diagnosis of cervical tuberculous lymphadenitis.