中文摘要：

研究认为幽门螺杆菌（Helicobacter pylori,H.pylori）感染是引起胃癌的一个重要因素,其包含的毒力基因及生活方式能够诱导胃上皮化生、癌变。但H.pylori引起胃癌的机制尚不清楚,已经成为一个公认的全球健康问题。大量的流行病学、临床和实验研究支持H.pylori是胃癌发生、发展过程中的启动和促动因子,做好H.pylori根除工作对于胃癌预后和预防至关重要。H.pylori疫苗的发展对于胃癌的防治提供了一种新的思路。本文旨在对H.pylori与胃癌相关性的研究进展作一概述。

英文摘要：

Helicobacter pylori （H. pylori） infection is an important correlation factor of inducing gastric cancer. Vir- ulence genes of H. pylori and lifestyle may affect gastric metaplasia and canceration, but the mechanism of H. pylori in- duced gastric cancer is still not clear, and H. pylori infection is recognized as a worldwide health problem. Numerous ep- idemiology, clinical and experimental studies support that H. pylori is the starting and actuation factor of the development of gastric cancer. H. pylori eradication therapy is essential in gastric cancer prognosis and prevention. The development of vaccines for the prevention of gastric cancer provides a new way of thinking. The research progress on the correlation between H. pylori and gastric cancer was reviewed.