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市售氯硝柳胺在斑点叉尾（鱼回）组织中的残留消除规律研究

ISSN号：1000-6907
期刊名称：《淡水渔业》
时间：0
分类：S948[农业科学—水产养殖;农业科学—水产科学]
作者机构：[1]中国水产科学研究院长江水产研究所,农业部淡水鱼类种质监督检验测试中心,武汉430223, [2]湖南省水产科学研究所,长沙410153, [3]淡水健康养殖湖北省协调中心,武汉430223, [4]中博水产生物技术有限公司,武汉430207
相关基金：公益性行业（农业）科研专项（201203085）;农业行业标准项目（11555）

作者：索纹纹[1,2], 刘永涛[1,3], 艾晓辉[1,3], 吕思阳[1], 杨秋红[1,3], 余少梅[4]

关键词：氯硝柳胺, 斑点叉尾(鱼回)(Ictalurus, punctalus), 消解, 残留, (鱼回), niclosamide , Ictalarus puctatus , degradation dynamics , residue

中文摘要：

为了研究氯硝柳胺在斑点叉尾（鱼回）（Ictalurus punctalus）组织中的残留消除规律，在静水条件下经安全性试验确定安全浓度后，直接对水族箱泼洒25％氯硝柳胺乙醇胺盐（NES）粉剂后采集斑点叉尾（鱼回）皮肤、肌肉和水样。采用高效液相色谱．质谱联用法（HPLC—ESI／MS／MS）测定样品中氯硝柳胺的浓度，结果表明，静水条件下25％氯硝柳胺乙醇胺对斑点叉尾（鱼回）的安全浓度为0．113mg／kg；养殖水环境中氯硝柳胺能快速消解，实验第2天即低于1μg／L，并呈无规律性持续较长时间；用药24h内，氯硝柳胺在鱼体肌肉和鱼皮中具有较强的蓄积能力，但48h后，其在鱼皮和肌肉中呈现快速消除至较低浓度，但后期消除缓慢，并会持续一定时间；氯硝柳胺（NIC）在斑点叉尾（鱼回）肌肉和鱼皮中的消除半衰期T1/2分别为10．66和9．24d，显著大于在水体中的消除半衷期。

英文摘要：

Accumulation and elimination of Niclosamide （NIC） in Ictalurus punctatus tissue and water under indoor static water laboratory test were studied. We took the method of splashing 25% Niclosamide ethanolamine salt（NES） under the safe concentration into aquarium after the safety testing and the same sizes of I. punetaus （ 133.42±26. 2） g were exposed to freshwater containing NES under static conditions. The concentrations of NIC in water and tissue （muscle, skin） samples were determined by liquid chromatography tandem mass spectrometric （HPLC-ESI/MS/MS）. The results showed that the safe concentration of 25% NES on 1. Punetaus was 0. 113 mg/L. NIC concentration in water decreased quickly on the first day, then it was lower than 1 p~g/L and maintained in a certain period, but the NIC concentration in muscle and skin presented enriched obviously on the first day, then the elimination trends started to level off and maintained a certain concentration fraction in a certain period. The elimination half-life of NIC in muscle and skin were 10. 66 and 9. 24, respectively, which were significantly higher than that in water.

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