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Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Titanium（IV） Complexes of N-Sulfonylated β-Amino Alcohols
  • ISSN号：1001-604X
  • 期刊名称：《中国化学：英文版》
  • 时间：0
  • 分类：O625.12[理学—有机化学;理学—化学] O625.42[理学—有机化学;理学—化学]
  • 作者机构：[1]tate Key Laboratory of Applied Organic Chemistry & Department of Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China
  • 相关基金：Project supported by the National Natural Science Foundation of China （Nos. 29925205, 30271488, 20021001 and 203900501）.
作者： 王少华[1], 涂永强[1], 陈鹏[1]
关键词： 对映选择性加成, 苯基乙炔, 酮, 催化反应, 钛(IV)化合物, N-磺酰二价基-β-氨基醇, 三炔丙基醇, asymmetric alkynylation, asymmetric catalysis, ketone, N-sulfonylated β-amino alcohol, tertiary propargylic alcohol
中文摘要：

容易准备了并且可重获的 chiral N-sulfonylated 氨基的酒精 2 在有 Ti 的联合(OPr -- 我) 发现是为酉同类的 alkynylzinc 的 enantioselective 增加的有效 chiral 催化剂的 4was，给了有用产品， chiral 第三级的 propargyl 白酒，与直到 92% 的 ee。

英文摘要：

The easily prepared and recoverable chiral N-sulfonylated fl-amino alcohol 2 in combination with Ti（OPr-i）4 was found to be an effective chiral catalyst for the enantioselective addition of alkynylzinc to ketones, which gave the useful products, i.e. chiral tertiary propargyl alcohols, with the ee up to 92%.

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期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175