4.4 A Resolution Cryo-EM structure of human mTOR Complex 1
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- 分类:N[自然科学总论]
- 作者机构:[1]Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China, [2]Key Laboratory of Molecular Medicine, Ministry of Education, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China, [3]State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China, [4]Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China, [5]National Center for Protein Science, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, [6]National Institute of Biological Sciences, Beijing 102206, China
- 相关基金:We thank staff members Biomedical Core Facility, Fudan University and National Center for Protein Science Shanghai for their help on Mass Spectrometry analyses. We thank the Tsinghua Cryo-EM Facility and High Performance Computation Facility of National Center for Protein Science Beijing for their support in cryo-EM data collection and processing. This work was supported by Grants from the National Natural Science Foundation of China (Grant Nos. U1432242, 31425008, 91419301), Basic Research Project of Shanghai Science and Technology Commission (No. 12JC1402700), the Program of Shanghai Subject Chief Scientist (,No. 14XD1400500).
作者:
Huirong Yang[1,2,3], Jia Wang[4], Mengjie Liu[1,2,3], Xizi Chen[1,2,3], Min Huang[5], Dan Tan[6], Meng-Qiu Dong[6], Catherine C. L, Wong[5], Jiawei Wang[4], Yanhui Xu[1,2,3], Hong-Wei Wang[4]
中文摘要:
Correspondence: jwwang@tsinghua.edu.cn
xuyh@fudan.edu.cn
hongweiwang@tsinghua.edu.cn