中文摘要：

研究了布洛芬对映体在含有疏水性L-酒石酸酯的1，2-二氯乙烷溶液及甲醇水溶液两相中的萃取分配行为，考察了不同烷基链长的L-酒石酸酯、D-酒石酸酯以及L-酒石酸酯的浓度、有机溶剂的种类和溶解布洛芬的甲醇水溶液浓度对分配系数K和分离因子α的影响。实验表明，L-酒石酸酯与布洛芬Ⅱ对映体形成的复合物稳定性比与布洛芬工对映体形成的复合物稳定性要大，而D-酒石酸酯的萃取性能则与此相反，它与布洛芬工对映体形成的复合物稳定性比与布洛芬Ⅱ对映体形成的复合物稳定性要大。有机溶剂的萃取性能为醇〉1，2-二氯乙烷〉烷烃，随着溶解布洛芬的甲醇水溶液中甲醇浓度的增大，分配系数K和分离因子α均降低，当甲醇的浓度为10％时，可以得到最佳的K和α。随着L-酒石酸酯浓度的提高，分配系数K和分离因子α先增大后减小，当L-酒石酸酯的浓度约为0．2mol·L^-1时，K和α达到最大值；L-酒石酸酯的碳链长度对分配系数K和分离因子α也有很大的影响。

英文摘要：

The distribution of ibuprofen enantiomers was examined in aqueous methanol solution and 1,2-dichloroethane organic solvent containing a chiral selector hydrophobic L-tartaric ester or D-tartaric ester. The influences of the length of alkyl chain of L-tartaric ester or D-tartaric ester, the concentration of L-tartaric ester, different organic solvents and the concentration of aqueous methanol solution on the partition coefficient （K） and separation factor （α） of ibuprofen, were investigated. L-tartaric ester formed more stable complex with Ⅱ-ibuprofen than with Ⅰ-ibuprofen- In contrast, D-tartaric ester formed more stable complex with Ⅰ-ibuprofen than with Ⅱ-ibuprofen. The extraction performance of organic solvents was different. For example, alcohols〉1, 2-dichloroethane〉alkanes. K and a were the highest when the concentration of aqueous methanol solution was 10%. With further increasing concentration of aqueous methanol solution, partition coefficient and separation factor decreased. With increasing concentration of L-tartaric ester, K and α increased firstly, and then decreased. K and a were the highest, when the concentration of L-tartaric ester was 0.2 mol · L^-1. The length of alkyl chain of L-tartaric esters and D-tartaric esters also had a great influence on K and α.