中文摘要：

目的探讨中国女性乳腺癌患者保乳术后大分割放疗期间的急性放射性毒性和生命质量情况。方法广州医科大学附属肿瘤医院符合入组条件的3 0 例乳腺癌保乳术后患者，年龄2 6 ?6 7 岁，随机分至大分割研究组（14 例）和常规分割对照组（16例）。全乳调强放疗剂量：大分割组40. 5Gy/15f/21d，常规分割组50Gy/25f/35d;瘤床加量：大分割组至46.5G y/16f/22d，常规分割组至60Gy/30f/42d。结果所有患者急性放射性皮炎均列为I ?II度，研究组和对照组急性皮肤毒性未见显著统计学差异（P > 0 .0 5 )。所有患者均未见明显放射性心、肺毒性出现。生命质量结果显示：除情感状况（EW B)指标研究组较对照组差<0. 0 5 )外，其余5 个指标（包括量表总得分TOTAL在内）两组得分均未见统计学差异（P > 0 . 05) 。结论中国女性乳腺癌患者保乳术后瘤床加量大分割放疗具有与常规分割放疗耐受良好，提示具有同等的急性毒性和生命质量情况。

英文摘要：

Objective To study the acute radioactive toxicity and life quality during hypofractionated radiotherapy afterbreast conserving surgery for Chinese female breast cancer patients. Methods 30 breast - cancer patients in the CancerCenter of Guangzhou Medical University, who were qualified for our study after breast conserving surgery, aged 26 ?27years, were randomly divided into two groups including hypofractionated experimental group (n = 14) or conventional fractionatedcontrol group ( 7i = 16) . Whole breast IMRT dose was 40. 5Gy/15f/21d for the experimental group and 50. 0Gy/25f/35d for the control group patients. The dose for tumor - beds was boosted to 46. 5Gy/16f/22d for the experimental group andto 60. 0Gy/30f/42 days for the control - group. Results The acute radioactive dermatitis in all patients was at degree I - II.There was no statistical differences between the experimental group and the control group in terms of acute radioactive dermatitis( P > 0. 05 ) . No obvious cardiac or pulmonary toxicity was observed in all patients. In respect of the life quality, the onlyindicator of EWB in the experimental group was significantly lower than that of the control group (P <0. 05) , and all otherfiver indicators including TOTAL were insignificantly different between the two group ( P >0. 05). Conclusion Hypofractionatedradiotherapy after breast conserving surgery shows good tolerance in Chinese female breast cancer patients, suggestingequal acute toxicity and life quality with conventional fractionated radiotherapy.