中文摘要：

目的：在H2O2胁迫下，研究玉米黄素增强成骨细胞抗自由基损伤的作用。方法：用H2O2作用成骨细胞，建立自由基损伤细胞模型。对模型组、药物组的细胞活力、SOD活性、ROS含量、LPO含量以及细胞膜流动性进行测定及比较。结果：模型组细胞活力、SOD活性、细胞膜流动性均比药物组有显著降低（P〈0．01），而ROS含量、LPO含量均比药物组有显著升高（P〈O．01）。结论：H2O2摄入会导致大鼠成骨细胞的氧化损伤，而玉米黄素可以预防或降低此类损伤对细胞的影响。

英文摘要：

Objective： To study the effect of zeaxanthin on enhancing the function of anti-oxidative damage of osteoblast. Methods： MC3T3-E1 Osteoblasts were randomly divided in five groups, including a control group,a model group,a medication group（low-dose, medium-dose, high-dose）, whose activity of cells and SOD,the content of ROS and LPO and membrane fluidity were tested and compared. Result： Compared with all medication groups,the activities of cells and SOD and membrane fluidity in the model group were significantly decreased（ P 〈0.01）. However, the content of ROS and LPO were significantly increased（ P 〈0.01）. Conclusion： H2O2 can cause oxidative damage of MC3T3-E1 osteoblast, but zeaxanthin can： prevent and decrease its influence.