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Pharmacokinetics and tissue distributions of veratric acid after intravenous administration in rats
  • ISSN号:2095-6975
  • 期刊名称:《中国天然药物:英文版》
  • 时间:0
  • 分类:R969.1[医药卫生—药理学;医药卫生—药学]
  • 作者机构:[1]School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
  • 相关基金:This work was supported by NSFC (Nos. 81274044 and 81073018).
中文摘要:

The present study was designed to investigate the pharmacokinetics and tissue distributions of veratric acid following intravenous administration in rats.The concentrations of veratric acid in rat plasma at various times after administrated at doses of 2.5,5,and 10 mg·kg–1 were quantified by HPLC.The tissue distributions of veratric acid at various times after a single intravenous dose of 2.5 mg·kg–1 were also analyzed.The plasma pharmacokinetic parameters at the three doses were as follows:t1/2,(86.23 ± 6.83),(72.66 ± 4.10) and(71.20 ± 2.90) min; C0,(11.10 ± 1.47),(23.67 ± 1.24) and(39.17 ± 3.90) μg·m L–1; and AUC0→∞,(1 240.90 ± 129.14),(2 273.84 ± 132.47) and(3 516.4 ± 403.37) min·μg·m L–1,respectively.The compound was distributed into tissues rapidly and extensively after intravenous administration and was mainly distributed into the liver,heart and kidneys.

英文摘要:

The present study was designed to investigate the pharmacokinetics and tissue distributions of veratric acid following intravenous administration in rats.The concentrations of veratric acid in rat plasma at various times after administrated at doses of 2.5,5,and 10 mg·kg^–1 were quantified by HPLC.The tissue distributions of veratric acid at various times after a single intravenous dose of 2.5 mg·kg^–1 were also analyzed.The plasma pharmacokinetic parameters at the three doses were as follows:t1/2,(86.23 ± 6.83),(72.66 ± 4.10) and(71.20 ± 2.90) min; C0,(11.10 ± 1.47),(23.67 ± 1.24) and(39.17 ± 3.90) μg·m L^–1; and AUC0→∞,(1 240.90 ± 129.14),(2 273.84 ± 132.47) and(3 516.4 ± 403.37) min·μg·m L^–1,respectively.The compound was distributed into tissues rapidly and extensively after intravenous administration and was mainly distributed into the liver,heart and kidneys.

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期刊信息
  • 《中国天然药物:英文版》
  • 北大核心期刊(2008版)
  • 主管单位:中华人民共和国教育部
  • 主办单位:中国药科大学 中国药学会
  • 主编:吴晓明
  • 地址:南京童家巷24号中国药科大学2号信箱
  • 邮编:210009
  • 邮箱:cpucjnm@163.com
  • 电话:025-83271565 83271568
  • 国际标准刊号:ISSN:2095-6975
  • 国内统一刊号:ISSN:32-1845/R
  • 邮发代号:28-306
  • 获奖情况:
  • 国内外数据库收录:
  • 美国国际药学文摘,美国化学文摘(网络版),波兰哥白尼索引,美国生物医学检索系统,美国科学引文索引(扩展库),美国生物科学数据库,中国中国科技核心期刊,中国北大核心期刊(2008版)
  • 被引量:6564