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中文摘要：
目的：探讨鼻腔-鼻窦内翻性乳头状瘤复发与恶变的临床特点、治疗及疗效。方法：回顾性分析29例鼻腔-鼻窦内翻性乳头状瘤复发与恶变患者的临床资料。结果：24例复发患者既往均有鼻腔鼻窦手术史，其中复发1次者17例，复发2次者6例，复发3次者1例，复发时间从术后1个月～14年。随访5个月～4年，平均随访时间为23个月，4例复发，术后复发率为16．7％（4／24），复发时间为术后3～5个月，复发患者均再次行手术治疗，其中1例术后病理提示伴有恶变并行术后放化疗，所有患者随访至今均未见肿瘤再次复发。5例恶变患者随访10个月～4年，3例术后辅以放化疗的肿瘤恶变患者中，1例复发2次并行手术治疗，1例死亡，另1例未见复发；另外2例未行术后放化疗患者，1例失访，1例存活至今未见复发。结论：积极、彻底的手术切除是治疗鼻腔-鼻窦内翻性乳头状瘤的首选方法，对于肿瘤多次复发与恶变患者必要时应辅以放、化疗，而术后定期的鼻内镜检查、鼻窦CT复查和长期甚至终生的随访对复发及恶变患者是非常重要的。
英文摘要：
Objective：To investigate the clinical characteristics,treatment and the effectiveness of sinonasal reverting papilloma with recurrence and malignant transformation. Method： Retrospective comparative analysis of sinonasal inverting papilloma with recurrence and malignant transformation treated from Jan. 2008 to Oct. 2012 in our hospital. Result：All the 24 patients with recurrence had the history of sinonasal surgery. Among them,17 patients recurred once,6 recurred twice and 1 recurred three times. The recurrence time was from 1 month to 14 years after operation. Four patients relapsed within half year after 5 months to 4 years follow-up and the recurrence ratio was 16.7 %（4/24）. All the 4 patients with recurrence had an operation once again and one of them was given chemoradiotherapy after surgery whose pathological results showed canceration. There was no recurrence among the all of 24 patients followed up until now. Among 5 patients with malignant transformation, 3 patients of them were given radiochemotherapy after surgery. Except 1 patient died of extensive recurrence, 1 received other operation after relapsed twice and 1 lost follow up,all the others were alive without recurrence during 10 months to 4 years. Conclusion：The surgical treatment with completely and positively is the firse choice and an effective management for sinonasal inverting papilloma. To the patients with recurrence on many times and malignant tumors, post-operative radiation or chemotherapy should he considered when needed.
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