中文摘要：

以含羟丙基-β-环糊精（HP-β-CD）手性识别剂的醇/盐双水相体系作为一种新型的手性识别萃取体系,研究了α-环己基扁桃酸（CHMA）对映体在其中的手性识别行为.考察了HP-β-CD浓度、CHMA浓度、乙醇和硫酸铵质量分数、体系温度和pH值等因素对CHMA对映体分配比（D）和分离因子（α）的影响.结果表明,含有手性识别剂HP-β-CD的乙醇/硫酸铵双水相体系对CHMA对映体具有很强的手性识别能力;体系中HP-β-CD浓度、乙醇质量分数、温度和pH值等因素对对映体的分离度影响较大;在体系温度为40℃、pH值为2、乙醇质量分数为30%、硫酸铵质量分数为15%、HP-β-CD的浓度为50 g/L及CHMA浓度为0.5 mmol/L时,手性识别分离效果最佳,分离因子α达到1.86.

英文摘要：

A novel alcohol/salt-based aqueous two-phase system containing chiral selector hydroxypropyl-β-cyclodextrin（HP-β-CD） for enantioselective liquid-liquid extraction was introduced.The chiral recognition of α-cyclohexyl-mandelic acid（CHMA） enantiomers was studied in this system.The effect factors of the distribution ratio（D） and the separation factors（α） on parameters such as the concentration of HP-β-CD,the concentration of CHMA,the mass fractions of C2H5OH and（NH4）2SO4,temperature and pH have been investigated.It was found that the C2H5OH-（NH4）2SO4-H2O aqueous two-phase system containing HP-β-CD as chiral selector showed a good chiral recognition ability toward CHMA enantiomers.It could be concluded that the enantioseparation strongly depended on the concentration of HP-β-CD,the mass fraction of C2H5OH,temperature and pH.The optimum conditions of enantioseparation were as follows： the temperature was 40 ℃,the pH was 2.0,the mass fractions of C2H5OH and（NH4）2SO4 were 30% and 15%,respectively,the concentration of HP-β-CD was 50 g/L,and the concentration of CHMA was 0.5 mmol/L.Under these conditions the separation factor（α） reached to 1.86.