目的:研究微花藤Iodes cirrhosa的化学成分。方法:利用多种色谱技术进行分离纯化,并通过现代波谱学和化学方法鉴定其结构。结果:从微花藤根95%乙醇提取物的水溶性部分分离得到24个化合物,分别鉴定为(-)-(7R,8S,7′E)-4,7,9,9′-四羟基-3,3′-二甲氧基-8,4′-氧木脂烷-7′-烯-9′-O-β-D-吡喃葡萄糖苷(1),(-)-(7S,8S,7′E)-4,7,9,9′-四羟基-3,3′-二甲氧基-8,4′-氧木脂烷-7′-烯-9′-O-β-D-吡喃葡萄糖苷(2),(+)-(7S,8S)-3,5-二甲氧基-4-羟基苯基丙三醇-8-O-β-D-吡喃葡萄糖苷(3),(+)-(7S,8S)-3-甲氧基-4-羟基苯基丙三醇-8-O-β-D-吡喃葡萄糖苷(4),(-)-(7S,8S)-4,7,9,9′-四羟基-3,3′-二甲氧基-8,4′-氧木脂烷-7-O-β-D-吡喃葡萄糖苷(5),(-)-(7R,8S)-4,7,9,9′-四羟基-3,3′-二甲氧基-8,4′-氧木脂素-4-O-β-D-吡喃葡萄糖苷(6),(-)-(2R)-1-O-β-D-吡喃葡萄糖基-2-{2-甲氧基-4-[1-(E)-丙烯-3-醇]苯氧基}丙烷-3-醇(7),(-)-(2R)-1-O-β-D-吡喃葡萄糖基-2-{2,6-二甲氧基-4-[1-(E)-丙烯3-醇]苯氧基}丙烷-3-醇(8),丁香脂素双葡萄糖苷(9),(-)-(7S,8R)-3-甲氧基-4-羟基苯基丙三醇-9-O-β-D-吡喃葡萄糖苷(10),(-)-(7R,8R)-3-甲氧基-4-羟基苯基丙三醇-9-O-β-D-吡喃葡萄糖苷(11),(-)-(7R,8R)-3,5-二甲氧基-4-羟基苯基丙三醇-9-O-β-D-吡喃葡萄糖苷(12),(-)-(7R,8R)-3-甲氧基-4-羟基苯基丙三醇-7-O-β-D-吡喃葡萄糖苷(13),11,13-二氢去酰基菜蓟苦素3-O-β-D-吡喃葡萄糖苷(14),獐牙菜苷(15),(-)-2-羟基-5-(2-羟乙基)苯基β-D-吡喃葡萄糖苷(16),(-)-(1′R)-1′-(3-羟基-4-甲氧基苯基)-乙烷-1′,2′-二醇-3-O-β-D-吡喃葡萄糖苷(17),(-)-4-羟基-3-甲氧基苯基-β-D-吡喃葡萄糖苷(18),(-)-3,5-二甲氧基-4-羟基苯基β-D-吡喃葡萄糖苷(19),(-)-3-羟基-1-(4-?
Objective: To investigate chemical constituents of Iodes cirrhosa.Method: Constituents were isolated by using a combination of various chromatographic techniques including column chromatography over silica gel,Sephadex LH-20,and C-18,as well as reversed-phase HPLC.Structures of the isolates were identified by spectroscopic and chemical methods.Result: Twenty-four compounds were obtained from a H2O-soluble portion of an ethanolic extract of the root of Iodes cirrhosa Turcz.Structures of the isolates were identified as(-)-(7R,8S,7′E)-4,7,9,9′-tetrahydroxy-3,3′-dimethoxy-8,4′-oxyneolign-7′-ene-9′-O-β-D-glucopyra-noside(1),(-)-(7S,8S,7′E)-4,7,9,9′-tetrahydroxy-3,3′-dimethoxy-8,4′-oxyneolign-7′-ene-9′-O-β-D-glucopyranoside(2),(+)-(7S,8S)-syringylglycerol 8-O-β-D-glucopyranoside(3),(+)-(7S,8S)-guaiacylglycerol 8-O-β-D-glucopyranoside(4),(-)-(7S,8S)-4,7,9,9′-tetrahydroxy-3,3′-dimethoxy-8,4′-oxyneolignan-7-O-β-D-glucopyranoside(5),(-)-alaschanisoside A(6),(-)-(2R)-1-O-β-D-glucopyranosyl-2-{2-methoxy-4-[1-(E)-propen-3-ol]phenoxyl}propane-3-ol(7),(-)-(2R)-1-O-β-D-glucopyranosyl-2-{2,6-dimethoxy-4-[1-(E)-propen-3-ol]phenoxyl}propane-3-ol(8),(-)-liriodendrin(9),(-)-(7S,8R)-guaiacylglycerol 9-O-β-D-glucopyranoside(10),(-)-(7R,8R)-guaiacylglycerol 9-O-β-D-glucopyranoside(11),(-)-(7R,8R)-syringylglycerol 9-O-β-D-glucopyranoside(12),(-)-(7R,8R)-guaiacylglycerol 7-O-β-D-glucopyranoside(13),(-)-11,13-dihydrodeacylcynaropicrin 3-O-β-D-glucopyranoside(14),(-)-sweroside(15),(-)-2-hydroxy-5-(2-hydroxyethyl)phenyl β-D-glucopyranoside(16),(-)-(1′R)-1′-(3-hydroxy-4-methoxyphenyl)ethane-1′,2′-diol-3-O-β-D-glucopyranoside(17),(-)-tachioside(18),(-)-3,5-dimethoxy-4-hydroxyphenyl β-D-glucopyranoside(19),(-)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone-3