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中文摘要：
自从 2009 流行 H1N1 猪起源流行性感冒，一个病毒(09 S-OIV ) 关于曾经变化的流行性感冒病毒的全球威胁提醒了世界，还考虑流行性感冒病毒的详细重新分类的许多问题仍然保持未答复。流行性感冒 A 病毒是流行流感的原因的代理人并且在它的表面上包含 2 主要 antigenic glycoproteins：(i) 红血球凝聚素(哈) ；并且(ii ) neuraminidase (NA ) 。09 S-OIV 的结构哈并且 NA 蛋白质(09H1 和 09N1 ) 最近在我们的实验室被解决了并且提供 09 S-OIV 重新分类病毒为什么与在人的严重后果是高度传染的一些线索。例如， 09H1 高度类似于在全面结构并且特别关于它的 5 的一个流行病毒定义的 1918 流行性感冒的 HA 抗体绑定 epitopes。为 09N1 ，它的很特殊的特征是活跃地点洞，它是以前预言了在所有 N1 NA 在场的150环的缺乏，并且我们假设150环可以在底层特性( 2,3 或 2,6 连接 sialic 酸受体)和流行性感冒 NA 的酶的机制起一个重要作用。有为 09 S-OIV 的特殊特征的 HA 和 NA 的联合可能在人贡献它的高增加的能递送。
英文摘要：
Since the 2009 pandemic H1N1 swine-origin influenza A virus （09 S-OIV） has reminded the world about the global threat of the ever changing influenza virus, many questions regarding the detailed re-assortment of influenza viruses yet remain unanswered. Influenza A virus is the causative agent of the pandemic flu and contains 2 major antigenic glycoproteins on its surface： （i） he- magglutinin （HA）; and （ii） neuraminidase （NA）. The structures of the 09 S-OIV HA and NA proteins （09H1 and 09N1） have re- cently been resolved in our laboratory and provide some clues as to why the 09 S-OIV re-assortment virus is highly infectious with severe consequences in humans. For example, the 09H1 is highly similar to the HA of the 1918 influenza A pandemic virus in overall structure and especially in regards to its 5 defined antibody binding epitopes. For 09N1, its most distinctive feature is the lack of a 150-1oop active site cavity, which was previously predicted to be present in all N1 NAs, and we hypothesize that the 150-loop may play a important role in the substrate specificity （α2,3 or α2,6 linked sialic acid receptors） and enzymatic mechanism of influenza NA. Combination of the HA and NA with special characteristics for the 09 S-OIV might contribute to its high increased transmissibility in humans.
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