中文摘要：

短暂禁食可引起包括糖皮质激素释放在内的一系列神经内分泌改变，对于疾病防治具有独特而重要的意义。本研究观察了短暂禁食对四氯化碳（carbon tetrachloride，CCl4）诱导的急性肝炎小鼠肝组织损伤程度及炎症反应水平的影响及其与糖皮质激素之间的可能关联。结果发现，短暂禁食可明显下调CCl。处理小鼠血浆中天冬氨酸转氨酶（aspartate transaminase，AST）及丙氨酸转氨酶（alanine transaminase，ALT）水平，显著减轻肝组织病理学改变，对肝组织内还原型谷胱甘肽（glutathione，GSH）含量无明显影响但可显著降低血浆中肿瘤坏死因子仪（tumor necrosis factor-α，TNF-α）及白介素-6（imerleukin-6，IL-6）浓度。糖皮质激素受体拮抗剂米非司酮不能阻断短暂禁食对转氨酶水平的下调作用，糖皮质激素受体激活剂地塞米松也不能模拟短暂禁食对转氨酶水平的下调作用。以上结果提示：短暂禁食可通过不依赖于糖皮质激素的途径抑制炎症反应、从而减轻CCl4诱导的急性肝炎。

英文摘要：

Short-term fasting could induce a series of neuroendocrine responses such as the release of glucocorticoid, which has unique and critical significance in the prevention and treatment of diseases. In the present study, the effects of short-term fasting on hepatic lesions and inflammatory response were investigated in a mouse model with carbon tetrachloride （CCl4）-induced acute hepatitis. In addition, the potential correlation between short-term fasting and glucocorticoid was also determined. The experimental data indicated that short-term fasting markedly down-regulated the level of aspartate transaminase （AST） and alanine transaminase （ALT） in the plasma and alleviated the histopathological abnormalities in the CCl4-treated mouse. Moreover, short-term fasting had no obvious effects on hepatic level of glutathione （GSH）, but it significantly decreased the concentration of tumor necrosis factor-α （TNF-α and interleukin-6 （IL-6） in plasma. The glucocorticoid receptor antagonist mifepristone could not block the suppressive effects of short-term fasting on transaminase level, and the glucocorticoid receptor agonist dexamethasone also could not mimic the suppressive effects of short-term fasting on transaminase level. The above results suggested that short-term fasting attenuated CCl4-induced inflammatory response and hepatic damage via a glucocorticoid-independent mechanism.