中文摘要：

目的 探讨家族性脂肪肝患者及其一级亲属代谢异常情况.方法 从参加山东大学附属省立医院在泰安市某县开展的“内分泌与代谢病”调查的2 000名调查人员中随机选取脂肪肝先证者及正常对照先证者,并收集其一级亲属资料;为排除环境和饮食的影响,除收集正常对照组外,还增加了对散发脂肪肝组的研究.经过性别、年龄匹配,共纳入191人,包括73个家系,73名先证者和118名一级亲属,根据先证者及一级亲属是否有脂肪肝,分为正常对照组、家族性脂肪肝组以及散发脂肪肝组.分别对各组的先证者、一级亲属的各项临床及实验室指标进行统计学分析.对于符合正态分布的计量资料,采用单因素方差分析进行组间比较和两两比较,对不符合正态分布者采用秩和检验进行比较;分类资料的比较采用χ2检验. 结果 先证者分析结果：家族性脂肪肝组及散发脂肪肝组先证者的腹型肥胖指标（体质量指数、腰围、臀围）都明显高于正常对照组先证者,差异具有统计学意义（P值均＜ 0.05）.一级亲属分析结果：家族性脂肪肝组一级亲属的腹型肥胖指标（体质量指数、腰围、臀围）以及血清尿酸、空腹血糖水平均明显高于正常对照组及散发脂肪肝组的一级亲属,差异具有统计学意义（P值均＜ 0.05）;而正常对照组与散发脂肪肝组之间无明显差异（P值均＞ 0.05）.家族性脂肪肝组一级亲属超重和（或）肥胖发生率以及高血糖患病率也明显高于正常对照组（χ2=12.83,P＜0.01;χ2=6.96,P＜0.01）及散发脂肪肝组一级亲属（χ 2=12.63,P＜0.01;χ2=12.22,P＜0.01）.结论 有脂肪肝家族史的个体更容易出现代谢异常（尤其是肥胖和血糖异常）,早期干预可能预防或延迟个体发生代谢综合征.

英文摘要：

Objective To investigate the metabolic disorders in patients of familial fatty liver disease and their first-degree relatives.Methods The probands with fatty liver disease and normal control probands were randomly selected from 2 000 persons who participated in the survey of＂endocrine and metabolic diseases＂ conducted by Provincial Hospital Affiliated to Shandong University in Taian,Shandong Province,China,and their first-degree relatives were enrolled.A normal control group and a group of sporadic fatty liver disease were established in order to eliminate the influence of environment and diet.A total of 191 subjects were enrolled after being matched for sex and age,including 73 families,73 probands,and 118 first-degree relatives.According to the presence or absence of fatty liver disease in probands and first-degree relatives,these subjects were divided into normal control group,familial fatty liver group,and sporadic fatty liver group.Clinical and laboratory markers were obtained from each group and statistical analyses were performed.A one-way analysis of variance was used for comparison of normally distributed continuous data between multiple groups or any two groups,the rank sum test was used for comparison of non-normally distributed continuous data,and the chi-square test was used for comparison of categorical data.Results The probands in the familial fatty liver group and sporadic fatty liver group had significantly higher abdominal obesity indices （body mass index,waist circumference,and hip circumference） than those in the normal control group （all P ＜ 0.05）.The first-degree relatives in the familial fatty liver group had significantly higher abdominal obesity indices （body mass index,waist circumference,and hip circumference）,serum uric acid,and fasting blood glucose than those in the normal control group and sporadic fatty liver group （all P ＜ 0.05）,while these parameters showed no significant differences between the normal control group and sporadic fatty liver group （P ＞