中文摘要：

FOXP3^＋调节性T细胞（Treg）是一类发挥免疫抑制及调节功能的T淋巴细胞亚群,其生理功能的可塑性对机体免疫稳态维持至关重要。FOXP3^＋Treg功能稳定性的失调与自身免疫疾病、肿瘤、过敏性和感染性疾病等人类重大疾病的发生发展密切相关。Forkhead家族转录因子FOXP3是Treg细胞特异性表达的关键转录因子,其功能稳定性受蛋白翻译后修饰酶类调控。通过筛选中药活性组分,开发靶向FOXP3翻译后修饰酶的小分子药物,从而实现FOXP3^＋Treg生理功能调控,将为重大疾病免疫相关治疗带来新思路、新靶点和新手段。

英文摘要：

FOXP3＇ Regulatory T cell（Treg） is a subset of T cells with the function of immunosuppression and immunoregulation, and its physiological stability plays a significant role in maintaining immune homeostasis in vivo. The instability and malfunction of FOXP3＇ Tregs are implicated in many major human diseases including autoimmune diseases, cancer, allergy and infectious diseases. As a key transcription factor specifically expressed in Treg, the stability of Forkhead family transcription factor FOXP3 is regulated by post-translational modification enzymes. By screening active ingredients in traditional Chinese medicine and developing small molecule drugs targeting FOXP3 post-translational modification enzymes, we expect to modulate the physiological stability of FOXP3＇ Treg and thus bring on new ideas, new targets and new therapeutic tools for the treatment of major human diseases.