中文摘要：

目的 观察接受低渗非离子型对比剂进行冠脉介入诊疗患者的肾功能变化，分析、评估对比剂肾病（CIN）的临床危险因素。方法 选择 2009 年 1 月至 2012 年 1 月在宁夏人民医院使用低渗非离子型对比剂行冠脉介入诊疗的患者452例，于介入术前、术后48-72小时分别查血清肌酐，分析比较 CIN 患者和非 CIN 患者年龄、性别、术前肌酐值以及合并临床危险因素的差异及对比剂剂量的差异。结果 452 例患者中有 28 例发生 CIN，424 例患者肾功能无恶化。CIN 患者年龄、术前肌酐值，合并高血压病、糖尿病、心衰、血容量不足的发病率及对比剂剂量均显著高于非 CIN 患者。结论 年龄、术前肾功能不全，对比剂剂量，合并高血压病、糖尿病、心力衰竭、血容量不足是冠脉介入术后 CIN 发生的重要临床危险因素。

英文摘要：

Objective To observe the effect of low permeability non - ionic contrast agent on renal function of patients with coronary intervention therapy, and to analyze the clinical risk factors of contrast - induced nephropathy （CIN）. Methods 452 patients adopted coronary interventional diagnosis and treatment with low permeability non ionic contrast agent were chosen in this research. All the patients accepted the percutaneous coronary intervention （PCI） in Ningxia people＇s Hospital between Jan. 2009 and Jan. 2012. ASerum creatinine of the 452 cases was detected before PCI, 48 h and 72 h after PCI respectively. Then, the disparity in ages, sex, foundation creatinine values as well as complicated hypertension, diabetes, heart failure, blood volume lack were analyzed between patients with CIN and non CIN patients. Results There were 28 cases of CIN, and 424 cases of patients with renal function without deteriorating in the 452 cases. The age of the patients, based creatinine values, complicated hypertension, diabetes, heart failure, blood volume lack and contrast agent in non CIN were significantly higher than those in patients with CIN. Contusion In addition to the dose of contrast agent, age, preoperative renal dysfunction, hypertension, diabetes, heart failure and inadequate blood volume before percutaneous coronary intervention are all the important clinical risk factors to CIN.