黄曲霉毒素(aflatoxin,AFT)是一类有毒致癌化合物,污染粮食及其制品,给人类及动物健康造成严最威胁。AFB2a是AFT的一种.作者对AFB2a的毒性、生物学活性及其抗体的反应性进行了综述。由于AFB2a的毒性远远低于AFB2a而且AFB2a抗体能与AFB2a及其在体内的代谢产物发生免疫学交叉反应,因此AFB2a的抗体。尤其是单克隆抗体对人、畜AFT中毒病的早期诊断、治疗、AFB1在体内的代谢转归、肿瘤预防以及食品卫生监测有着非常重要的意义,而有关AFB2a的单克隆抗体方面的研究,国内还未见报道。
Aflatoxin is a kind of toxic and carcinogen compound, which polluted rice and products. It is serious harmfulness to the health of experimenter, human being and animal. Aflatoxin B2, is a kind of the aflatoxin. This essay summarized the toxicity and biological activity of AFB2, and reactivity of antibody. As the toxicity of AFB2a, was lower than AFB2a, and the antibody can act on AFB1, AFB1-DNA adducts and related metabolites, so the broad specincity AFB2a, antibody might be of considerable value in the detection of AFB1- DNA adducts or related metabolites, prevent tumor,discarding toxic of rice and it's products and the prophase diagnose of aflatoxicosis. But the reporting about AFB2a Monoclonal antibody was absence in China.