中文摘要：

目的：观察四君子汤及其拆方对D-半乳糖（D—gal）诱导小鼠衰老模型的免疫调节作用。方法：用D-半乳糖诱导小鼠衰老模型，采用花环和脾淋巴细胞转化试验（MTT法）测定模型小鼠红细胞免疫和T细胞免疫功能；采用试剂盒对丙二醛（MDA）、超氧化物歧化酶（SOD）及谷胱甘肽过氧化物酶（GSH—Px）等氧化抗氧化指标进行检测。结果：四君子汤能显著提高D-半乳糖诱导衰老小鼠的T淋巴细胞转化能力（P〈0．05），显著提高C3b孙花环率（P〈0．05），显著降低IC花环率（P〈0．05），并能显著提高其血清SOD及GSH—Px活性（P〈0．01），显著降低血清MDA含量（P〈0．05）。结论：四君子汤党参、白术对D-半乳糖（D—gal）诱导衰老模型小鼠有免疫调节作用，而茯苓、甘草无明显作用。

英文摘要：

Objective ： To observe the immunomodulatory effects of codonopsis, atractylodes macrocephala, tuceahoe, broiled licorice and sijunzi decoction on D-galaetose-induced aging mice. Methods： The models of aging mice were induced by D-galactose, the garlands and splenic lymhocyte transformation test （MTT） were used to determine the ability of erythroeytes immune and lymphocytes conversion; The content of maleic dialdehyde （MDA） , activity of superoxide dismutase（SOD） and glutathione pemfidase（GSH-Px） in serum were dectected. Results： Sijunzi decoction and its disassembled prescription codonopsis could significantly increase the ability of T lymphocyte transformation（ P 〈 0. 05 ） ; Atractylodes macrocephala and sijunzi decoction could significantly enhance C3b garlands ratio （P 〈 0. 05 ） and decrease IC garlands ratio（ P 〈 0. 05 ） on D-galactose-induced aging mice. Sijunzi decoction significantly increased the activity of SOD and GSH-Px （P 〈 0.01 ）, and decreased the content of MDA in serum（ P 〈 0.05 ）. Conclusion： Sijunzi decoction and its disassembled prescription codonopsis, atraetylodes maerocephala can improve the immunomodulatory effects on D-galactose-indueed aging mice; but tuceaboe and boriled icoriee have no obvious effects.