中文摘要：

为了探讨不同抗生素对0 ～28日龄岭南黄肉鸡生产性能和肠道免疫水平的影响,试验选用体型均匀、体重接近的1日龄岭南黄肉鸡240只、采用单因子完全随机区组设计,分为4组,每组3个重复,每个重复20只.Ⅰ组为对照组,饲喂不含抗生素的基础日粮,Ⅱ、Ⅲ和Ⅳ组为试验组,分别添加4 mg/kg的盐酸林可霉素、50 mg/kg杆菌肽锌及20 mg/kg硫酸粘杆菌素.结果表明：与Ⅰ组相比,三种抗生素均能显著提高岭南黄肉鸡的日增重（P＜0.05）,对料肉比影响则不显著（P＞0.05）；仅盐酸林可霉素能显著提高岭南黄肉鸡的采食量（P＜0.05）.Ⅱ组、Ⅲ组十二指肠和回肠TLR2 mRNA表达量显著降低（P＜0.05）,Ⅳ组回肠段TLR4 mRNA表达量显著降低（P＜0.05）.Ⅱ、Ⅲ组肉鸡的肠道IL-6、TNF-α、n-10的mRNA基因水平显著降低（P＜0.05）,同时sIgA分泌量减少（P＜0.05）.Ⅳ组肉鸡肠道炎症细胞因子基因mRNA水平并未出现降低（P＞0.05）,但sIgA分泌量增加（P＜0.05）.结论：三种抗生素均可提高岭南黄肉鸡的日增重,并能降低肉鸡肠道免疫水平.

英文摘要：

This experiment was conducted to study the effect of different antibiotics on the growth perform- ance, intestinal microflora and intestinal immunity of Lingnan yellow broiler. 240 one-day-old Lingnan yellow broilers were randomly divided into four groups with three replicates for each group and twenty lingnan yellow broiders for each replicate. The four groups were fed with a basal diet （ group I ）, basal diet ＋ 4 mg/kg Linco- mycin Hydrochloride （ group Ⅱ ）, basal diet ＋ 50 mg/kg Zinc Bacitracin （ groupⅢ ）, basal diet ＋ 20 mg/kg Colistin sulfate （group IV ） respectively and the feeding experiment lasted 28 days. The results showed as fol- lows：compared with the control group, the daily gains of lingnan yellow broilers in group II , m and IV weresignificantly higher （ P 〈 0.05 ） and the average daily feed intake was higher only in group Ⅱ （ P 〈 0.05 ）, but F/G was not significantly developed in group Ⅱ , Ⅲ and Ⅳ （P 〉 0.05 ） ; the expression of TLR2 mRNA in the duodenum and Ileum reduced respectively （ P 〈 0. 05 ） ; the expression of TLR4 mRNA in the Ileum decreased significantly （P 〈 0.05 ） ;The relative expression levels of IL -6, TNF -α and IL- 10 in groups Ⅱ and Ⅲ re- duced significantly , at same time the release of sIgA of the intestinal reduced too （ P 〈 0.05 ）. The relative ex- pression level of IL-6 ,TNF-α and IL- 10 in group IV were influenced significantly （P 〉0.05 ） but the re- lease of sIgA increased （ P 〈 0.05 ）. In conclusion, the supplementation of different antibiotics can improve growth performance and influence the microflora in the intestinal and affect the immune function of the intesti- nal in lingnan yellow broiler