中文摘要：

细菌第二信使环二鸟苷酸（c-di-GMP）信号网络系统主要涉及信号代谢、识别、接受、传递、功能表达和调控。c-di-GMP胞内水平受到鸟苷酸环化酶（DGC）和磷酸二酯酶（PDE）的控制。c-di-GMP信号受体类型多样,包括转录调控因子、PilZ结构域蛋白、退化的GGDEF和EAL结构域蛋白、核糖体开关、多核苷酸磷酸化酶和新发现的蛋白激酶等。c-di-GMP受体接受信号后,可以在转录、翻译以及翻译后水平上对下游靶标进行调控,从而影响细菌的毒性、运动性、生物膜形成、细胞分裂等生理生化过程。本文结合本实验室对水稻白叶枯病菌的研究结果,综述了近年来国内外在c-di-GMP信号受体介导的调控机制等方面的研究进展。

英文摘要：

The bacterial second message c-di-GMP signaling pathways mainly involve signal metabolism, signal rec- ognition by receptor, reception and transduction, and phenotype expression and regulation. The intracellular level of c-di-GMP is precisely controlled by diguanylate cyclases （DGC） and phosphodiesterase （PDE） via biosynthesis or degradation, respectively. Several c-di-GMP receptors have been identified and characterized from various bac- terial species, including transcription regulator, PilZ-domain protein, degenerate GGDEF or EAL domain pro- tein, polynucleotide phosphorylase （PNPase）, riboswitch and kinase, etc. The c-di-GMP receptors exert their reg- ulatory functions at the transcription, translation, and post-translation levels, and regulate multiple bacterial properties including virulence, biofilm formation, motility and cell division. The recent progresses in c-di-GMP receptor-mediated regulation of bacterial behaviors were here reviewed, in combination with some of our findings on the bacterial blight pathogen of rice Xanthomonas oryzae pv. oryzae.