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神经干细胞和缺血性脑卒中研究进展
  • ISSN号:2095-3240
  • 期刊名称:中华针灸电子杂志
  • 时间:2012.8
  • 页码:23-27
  • 分类:S562.01[农业科学—作物学] TS972.161[轻工技术与工程]
  • 作者机构:[1]Institute of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China, [2]Tianjin Key Labora- tory of Acupuncture and Moxibustion Science, Tianjin 300193, China
  • 相关基金:Supported by The National Science and Technology Infra- structure Program of China (2006BAI04A02-2), the National Basic Research Program of China (2012CB518505) and the Natural Science Foundation of China (81173416)
  • 相关项目:基于microRNA负调控途径探讨针刺诱导脑缺血后神经发生机制
中文摘要:

目的将为击的处理评估 Danqipiantan 囊(DPC ) 的功效和安全。方法 PubMed,中国科技杂志数据库, Wanfang 数据库,在中国知识基础结构的中国期刊,和天津医药大学的图书馆的医院将军被寻找直到 2012 年 7 月。使随机化的控制试用(RCT ) 和报导为击的处理的 DPC 的使用被选择的观察研究。结果包括了 12 RCT 的十一篇文章,和包括了 3 观察研究的 2 篇文章被识别。2590 个病人的一个总数参予了研究。我们发现以有效的率 DPC 治疗组和控制组之间有重要统计差别[风险比率(RR ) , 1.14;95% 信心间隔(CI ) , 1.04, 1.25;P=0.01 ] , Fugl-Meyer 评价规模[加权的吝啬的差别(WMD ) , 9.77;95% CI (4.84, 14.70 ) ;P=0.00 ] , Barthel 索引[WMD=6.40;95% CI (3.15, 9.65 )] ,并且吝啬的流动速度[WMD= 5.79;95% CI (1.64, 9.94 )] 。为健康中风规模的国家研究所没有重要差别[WMD=0.60;95% CI (1.09, 2.29 )] ,视觉领域缺点[左视觉地:WMD= 203.10;95% CI (424.41, 18.21 ) ;恰好视觉的地:WMD= 172.60;95% CI (409.29, 64.09 )] 或功能的独立措施[WMD= 7.90;95% CI (16.64, 0.84 )] 。包括了八 RCT 的七篇文章报导了 DPC 治疗的安全。包括了三观察研究的二篇文章也为 DPC 报导了有益的效果。因为中国研究具有样品的差的方法学的质量,和大多数,尺寸是小的,我们的分析被偏爱多半影响。结论 DPC 有有益的效果并且当为击的处理使用了时,是相对安全的。

英文摘要:

OBJECTIVE: To evaluate the efficacy and safety of Danqipiantan capsule (DPC) for the treatment of stroke. METHODS: PubMed, China Science And Technolo- gy Journal Database, Wanfang Database, Chinese periodicals in the China National Knowledge Infra- structure, and the General Hospital of Tianjin Medi- cal University's Library were searched until July 2012. Randomized controlled trials (RCTs) and ob- servational studies that reported the use of DPC for treatment of stroke were selected. RESULTS: Eleven articles that included 12 RCTs, and 2 articles that included 3 observational studies were identified. A total of 2590 patients participat- ed in the studies. We found that there was a signifi-cant statistical difference between DPC treatment groups and the control groups in terms of the effec- tive rate [risk ratio (RR), 1.14; 95% confidence inter- vals (CI), 1.04, 1.25; P=0.01], FugI-Meyer Assessment Scale [weighted mean difference (WMD), 9.77; 95% CI (4.84, 14.70); P=0.00], Barthel Index [WMD=6.40; 95% CI (3.15, 9.65)], and mean flow velocity [WMD= 5.79; 95% CI (1.64, 9.94)]. There were no significant differences for The National Institutes of Health Stroke Scale [WMD=0.60; 95% CI ( - 1.09, 2.29)], vi- sual field defects [left visual field: WMD= - 203.10; 95% CI ( - 424.41, 18.21); right visual field: WMD= - 172.60; 95% CI ( - 409.29, 64.09)] or the functional independence measure [WMD= - 7.90; 95% CI ( - 16.64, 0.84)]. Seven articles that included eight RCTs reported the safety of DPC treatment. Two ar- ticles that included three observational studies also reported beneficial effects for DPC. Because the Chinese studies were of poor methodological quali- ty, and most of the sample sizes were small, our analysis was likely affected by bias. CONCLUSION: DPC has a beneficial effect and is relatively safe when used for the treatment of stroke.

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期刊信息
  • 《中华针灸电子杂志》
  • 主管单位:中华人民共和国卫生部和计划生育委员会
  • 主办单位:中华医学会
  • 主编:
  • 地址:天津市南开区鞍山西道314号A座14层008室
  • 邮编:300193
  • 邮箱:chinaacumox@163.com
  • 电话:022-27432618
  • 国际标准刊号:ISSN:2095-3240
  • 国内统一刊号:ISSN:11-9326/R
  • 邮发代号:
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:386