中文摘要：

目的建立低温粉碎结合超声萃取-气相色谱-质谱联用法测定高分子食品包装材料中二苯基醚、4,4’-二甲基二苯醚、4,4’-二羟基二苯醚、三氯生等4种抗菌剂残留量的分析方法。方法样品经液氮冷冻粉碎后,通过采用丙酮-二氯甲烷混合溶液超声萃取,DB-5ms色谱柱分离,气相色谱-质谱法（gas chromatography-mass spectrometry,GC-MS）选择离子扫描模式（SIM）检测以及外标法定量来进行检测分析。结果当丙酮-二氯甲烷混合溶液的配比为3：7（V：V）时,结果最佳。在优化条件下检测,4种抗菌剂在0.2~10 mg/L范围内线性良好,线性相关系数大于0.99,回收率为84.7%~104.7%,相对标准偏差RSD为3.2%~12.9%,方法定量限为2.0 mg/kg。结论该方法简便、快捷、准确,适合对高分子食品包装材料中二苯基醚、4,4’-二甲基二苯醚、4,4’-二羟基二苯醚、三氯生残留量进行检测分析。

英文摘要：

Objective To establish a method for determination of 4 kinds of antimicrobials（diphenyl ether, 4,4＇-dimethydiphenyl ether, 4,4＇-oxydiphenol and triclosan） in polymeric antimicrobial food-packaging materials by cryogenic comminution and ultrasonic extraction tandem with gas chromatography-mass spectrometry（GC-MS）. Methods Samples were freezing-smashed with liquid nitrogen, extracted by mixed solvents of acetone and dichloromethane with ultrasonic, separated by DB-5ms column, detected by GC-MS, and quantitated by external standard method. Results The best optimal proportion of acetone and dichloromethane was 3：7（V：V）. Under optimized conditions, a good linear of 4 antimicrobial were showed between 0.2~10 mg/L, with correlation coefficients（r） above 0.99. The recoveries were ranged from 84.7% to 104.7%, the relative standard deviations（RSDs） were between 3.2%~12.9%, and the limits of quantization（LOQ） were 2.0 mg/kg. Conclusion The proposed method is rapid, accurate and sensitive, which is suitable for detecting diphenyl ether, 4,4＇-dimethydiphenyl ether, 4,4＇-oxydiphenol and triclosan in polymeric antimicrobial food-packaging materials.