中文摘要：

目的对冠脉内注射小剂量乌拉地尔对防治靶血管开通后的无复流现象的作用进行初步研究。方法我院收治的急性心肌梗死患者并行急诊介入治疗者共48例随机分为为乌拉地尔组（术中加用乌拉地尔冠脉内注射）和对照组（各24例）。比较两组患者的术后心肌灌注分级和无复流的发生率。结果乌拉地尔组术后梗死相关血管血流Blush分级无复流发生率，显著低于对照组（16.67%vs29.2%）P〈0.05。结论冠脉内注射小剂量乌拉地尔对急性心肌梗死直接介入治疗后无复流现象有一定防治作用。

英文摘要：

Objective To investigate the effects of intracoronary bolus of the selective 1-antagonist Urapidil on myocardial perfusion after coronary stenting. Methods Patients from November 2005 to May 2006 who underwent successful coronary reperfusion with primary coronary angioplasty within 12 h after the onset of AMI were divided into Urapidil group （ n = 24） and the control group （ n = 24）. For the Urapidil group, 8mg Urapidil were injected into the coronary artery. Ten minutes after stenting, coronary angiographys were redone for comparisons of blush grading and reflow frequency. As for the control group, coronary angiographys were repeated ten minutes too. Results The clinical significances showed no significant differences between Urapidil group and control group, but according to the blush grading ten minutes after stenting, the occurance rate of no-reflow phenomenon was lower in the Urapidil group than in control group（ 16.67 % vs 29.2 %, P 〈 0.05. ）. Conclusion Low dose Urapidil exhibits beneficial effects on preventing no-reflow in patients with acute myocardial infarction.