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肿瘤相关糖抗原STn硫苷类似物的合成
  • ISSN号：1003-1057
  • 期刊名称：《中国药学：英文版》
  • 时间：0
  • 分类：R916.41[医药卫生—药学]
  • 作者机构：[1]北京大学天然药物及仿生药物国家重点实验室,北京100191
  • 相关基金：Foundation item： National Natural Science Foundation of China （Grant No. 20732001）.Acknowledgements This work was supported by Program for National Natural Science Foundation of China （Grant No. 20732001）.
作者： 霍常鑫[1], 叶新山[1]
关键词： 糖, 肿瘤相关抗原, STN, 合成, Carbohydrate, Tumor-associated antigen, STn, Synthesis
中文摘要：

对肿瘤相关糖抗原进行小的结构修饰有可能发现新的抗肿瘤疫苗。由于硫苷具有对内源性糖苷酶的耐受性和非自身抗原特性,因此用S-连接的糖苷键代替O-连接的糖苷键对糖抗原进行修饰可能导致比天然的o-连接糖抗原更强的免疫原性,并可能刺激产生能够识别天然寡糖的抗体。为达此目的,我们成功完成了一个新的肿瘤相关二糖抗原STn的S-连接类似物的合成。

英文摘要：

Modified tumor-associated carbohydrate antigens could be used to develop anti-cancer vaccines.Carbohydrate antigens in which thioglycosidic linkages are used instead of O-glycosidic linkages may be more immunogenic and may stimulate the production of antibodies capable of recognizing naturally occurring carbohydrates due to their enhanced resistance to endogenous glycosidases and their inherent non-self antigen character.For this purpose,a new S-linked tumor-associated carbohydrate antigen STn has been successfully synthesized for the first time.

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寡糖化合物的合成研究方法及应用
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期刊信息
  • 《中国药学：英文版》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:北京大学药学院
  • 主编：王夔
  • 地址：北京市学院路38号
  • 邮编：100083
  • 邮箱：zggy@mail.bjmu.edu.cn
  • 电话：010-82801713
  • 国际标准刊号：ISSN：1003-1057
  • 国内统一刊号：ISSN：11-2863/R
  • 邮发代号:
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:708