中文摘要：

背景 P53 是在癌症研究的大多数学习肿瘤 suppressors 之一，并且超过 50% 人的肿瘤带 P53 变化。MDM-2 被放大或在多样的织物的许多人的肿瘤的 overexpressed 起源。这研究的目的是在 gliomas 检验 P53 蛋白质和 MDM-2 蛋白质的表示，并且调查在二蛋白质的表示和 glioma 的组织病理学说的等级之间的关系。在 MDM-2 蛋白质表示和 P53 蛋白质表示之间的关系也是 analyzed.Methods P53 蛋白质和 MDM-2 蛋白质的表示 immunohistochemically 在 242 石蜡用 monoclonal 抗体被检测嵌入纸巾，包括从有 craniocerebral 损害的病人的 30 正常大脑纸巾和从有主要 glioma 的病人的 212 纸巾(等级 - 组：等级的 5 个案例，等级的 119 个案例；并且分级 - 组织：等级的 53 个案例，和等级的 35 个案例).Results P53 积极的率比在控制组(P 0.0001 ) 在 glioma 组是显著地更高的。P53 积极的率比在等级的 glioma 纸巾在等级 -V 的 glioma 纸巾是显著地更高的 - 组(P=0.001 ) 。MDM-2 积极的率比在控制组(P 0.0001 ).There 不是处于在二个 glioma 组(P=0.936 ) 之间的 MDM-2 积极的率的重要差别的在 glioma 组是显著地更高的。P53 蛋白质的表示不与 P53 蛋白质的蛋白质(P=0.069 ) 结论 Overexpression 可能与出现有关的 MDM-2 的表示有关， MDM-2 蛋白质的 glioma.Overexpression 的前进可以在 glioma tumorigenesis 起一个重要作用，但是不能涉及 glioma 前进。MDM-2 蛋白质的 overexpression 是在 glioma 的恶意的转变的一个早事件。MDM-2 可以是在在它的自己的权利的 glioma 的一个关键播放器。

英文摘要：

Background P53 is one of the most studied tumor suppressors in the cancer research, and over 50% of human tumors carry P53 mutations. MDM-2 is amplified and/or overexpressed in a variety of human tumors of diverse tissue origin. The aim of this study was to examine the expression of P53 protein and MDM-2 protein in gtiomas, and to investigate the relationship between the expression of the two proteins and the histopathological grades of glioma. The relationship between MDM-2 protein expression and P53 protein expression was also analyzed. Methods The expression of P53 protein and MDM-2 protein was immunohistochemically detected using monoclonal antibodies in 242 paraffin embedded tissues, including 30 normal brain tissues from patients with craniocerebral injury and 212 tissues from patients with primary glioma （grade Ⅰ-Ⅱ group： 5 cases of grade Ⅰ, 119 cases of grade Ⅱ; and grade Ⅲ-Ⅳ group： 53 cases of grade Ⅲ, and 35 cases of grade Ⅳ）. Results The P53 positive rate was significantly higher in the glioma groups than in the control group （P 〈0.0001）. The P53 positive rate was significantly higher in glioma tissues of grade Ⅲ-Ⅳ than in glioma tissues of grade Ⅰ-Ⅱ group （P=-0.001）. The MDM-2 positive rate was significantly higher in glioma groups than in the control group （P 〈0.0001）. There was no significant difference in the MDM-2 positive rate between the two glioma groups （P=0.936）. The expression of P53 protein was not related to expression of MDM-2 protein （P=-0.069） Conclusions Overexpression of P53 protein might be related to the occurrence and progression of glioma. Overexpression of MDM-2 protein may play an important role in glioma tumorigenesis, but may not be involved in glioma progression. The overexpression of MDM-2 protein was an early event in malignant transformation of glioma. MDM-2 may be a key player in glioma in its own right.