中文摘要：

设计并制作了一种PMMA材料的微流控检测芯片，利用外界气体驱动液体，用于实验样品的分析和检测。芯片的整体尺寸为86mm×60mm×4．5mm，利用精密加工的方法进行加工。采用一种简单实用的溶胶一凝胶改性方法对微通道管路进行亲水处理，实验证明亲水性有明显提高。并分析了亲水性提高的机理。提出一种新的溶剂键合方法，在室温下对芯片进行键合。溶剂为二氯乙烷和无水乙醇按1：1混合的混合液。分析了不同溶液配比、键合时间和键合压力对键合效果的影响。同时，芯片上集成了多个阀，对阀膜材料的选择、粘接工艺进行了研究。

英文摘要：

A new type of plastic microfluidic detection chip was developed for analyzing and testing samples. The size of the chip is 86 mm × 60 mm × 4.5 mm. Gas is used to drive the fluid. The chip was fabricated using precision machining method. A simple hydrophilic modification method was applied for microchannels. Experiment results prove that the hydrophilicity is markedly improved. The mechanism of the hydrophilicity improvement is also analyzed. The chip was bonded in room temperature with a dichloroethane-alcohol mixture mixed in a ratio of 1 ： 1. The influence to the bonding result is analyzed for different mixture ratio, bonding time and bonding pressure. Several valves were integrated in the chip. The adhesion technology of the valve membrane was studied.