中文摘要：

背景：有研究表明巨噬细胞移动抑制因子是具有多种生物活性的细胞因子,在机体的炎症和免疫反应中起重要作用。巨噬细胞移动抑制因子rs1007888已被报道与多种炎症性疾病相关,但其与哈萨克族冠状动脉粥样硬化性心脏（冠心病）病易感性是否具有关联性少见报道。目的：探讨巨噬细胞移动抑制因子rs1007888位点基因多态性与新疆哈萨克族人群冠心病之间的相关性。方法：选择2012年6月至2014年4月于新疆医科大学附属第一医院心脏中心入院,经皮冠状动脉造影检查确诊的哈萨克族冠心病患者230例为冠心病组,以同期冠脉造影阴性、排除冠心病诊断的478例哈萨克族为健康对照组。采用实时荧光定量PCR法对所有纳入对象巨噬细胞移动抑制因子rs1007888位点基因多态性进行检测,比较两组间巨噬细胞移动抑制因子基因多态性频率分布的差异。结果与结论：冠心病组与对照组基因型分布符合Hardy-Weinberg平衡（P〉0.05）,两组的巨噬细胞移动抑制因子rs1007888位点基因型、等位基因频率均差异无显著性意义（P〉0.05）。结果证实,rs1007888位点基因多态性与新疆维吾尔自治区哈萨克族冠心病发病无显著相关性,该位点突变可能不是哈萨克族人群冠心病的易感因素。

英文摘要：

BACKGROUND：Macrophage migration inhibitory factor （MIF） is a multi-potent cytokine that makes considerable contribution to the regulation of inflammatory response and immune response in the body. MIF rs1007888 is associated with various inflammatory diseases, but the correlation between rs1007888 and coronary heart disease in the Kazakhs of China has been rarely explored. OBJECTIVE：To investigate the relationship between rs1007888 gene polymorphisms in MIF gene and coronary heart disease in the Kazakhs from Xinjiang Uygur Autonomous Region, China. METHODS：A total of 230 Kazakh patients with coronary heart disease evidenced by coronary arteriography between December 2012 and July 2014 were recruited, and another 478 Kazak controls were free from coronary artery disease with normal angiograms. Real-time fluorescence quantitative PCR assay was used to detect the rs1007888 polymorphisms of MIF gene. Alele and genotype distributions of the rs1007888 polymorphism were compared between patients and controls. RESULTS AND CONCLUSION：Distribution of genotypes in the two groups appeared to be in Hardy-Weinberg equilibrium （P〉 0.05）. The alele frequencies and genotypes of MIF-rs1007888 showed no significant difference between the two groups （P 〉 0.05）. Therefore, the genetic variation of rs1007888 in MIF gene is not associated with coronary heart disease in the Kazakhs of China.