中文摘要：

合成了2-甲酰噻吩缩氨基硫脲化合物L1,L2和它们的芳基钌配合物[（η6-p-cymene）RuII（TSC）Cl]Cl（1：TSC=L1,2：TSC=L2）,其结构经1H NMR,MS和元素分析确认.通过单晶培养得到了1的晶体,并测定其晶体结构.凝胶电泳实验表明,L1和L2与1和2对pBR322质粒DNA存在不同的作用机理.采用MTT法测定了这些化合物对3种人体肿瘤细胞株（SGC7901,BEL7404和CNE-1）的细胞毒活性.其中化合物1对人鼻咽癌细胞株（CNE-1）的有较好的抑制活性,其IC50值为27.8μmol L-1.

英文摘要：

Two 2-formylthiophene thiosemicarbazone compounds （L1, L2） and the ruthenium（II） arene complexes [（η6-p-cymene）Ru11（TSC）C1]C1 （1： TSC=L1, 2： TSC=L2） have been synthesized. The complexes were characterized by IH NMR, MS and elemental analysis. The crystal structure of 1 is determined by single-crystal X-ray diffraction. The gel electro- phoresis results show that the reaction mechanism for L1/L2 and 1/2 with pBR322 plasmid DNA is different. The in vitro anticancer activities of these complexes have been evaluated against three human cancer cell lines （SGC7901, BEL7404 and CNE-1）, and 1 is proved to be the most efficient inhibitor with IC50 values of 27.3 pmol·L-1 against CNE-I.