中文摘要：

利用乙肝病毒表面抗原转基因（HBs-Tg）小鼠与78T细胞缺陷型（TCRδ^-／-）小鼠杂交，筛选出HBs-Tg-TCRδ^-/-小鼠．采用腹腔连续注射四氯化碳（CCl。）的方式建立了小鼠肝纤维化模型，探讨了γδT细胞在HBs-Tg小鼠肝纤维化模型中的作用．结果表明：与HBs-Tg小鼠相比，HBs-Tg-TCRδ^-/-小鼠反映肝损伤和肝纤维化的相关指标ALT及a-SMA，TIMPl，COllal基因表达水平显著增高-肝纤维化更为严重-γδT细胞在HBs-Tg小鼠肝纤维化模型中具有保护作用．为今后γδT细胞对肝纤维化的治疗奠定了一定基础．

英文摘要：

γδT cells is one subset of T cells and serve as a bridge between innate and adaptive immune responses. TaT cells also play regulatory roles in anti-tumor,virus infection and autoimmune diseases. In this study, using HBs-Tg mice crossed with TCRδ^-/- mice to obtain HBs-Tg-TCRδ^-/- mice, explored the role of γδT cells in CC14-induced liver fibrosis of HBs-Tg mice. The results demonstrated that ALT, a-SMA, TIMP1, COllal levels of HBs-Tg-TCRδ^-/- mice were significantly higher than HBs-Tg mice, and γδT cells of HBs-Tg mice played a protective role in CC14-indueed liver fibrosis. The results provided the foundation for further research of liver fibrosis treatment via γδT cells.