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中文摘要：
采用乳化-化学交联法制备了盐酸环丙沙星-ε-聚赖氨酸（CH_PL）微球。利用扫描电镜、红外光谱和ZetasizeNanoZS对载药微球进行表征，并考察了CH—PL微球在0．1mol／LHCl（pH=1．2）溶液中的释药行为以及不同交联剂用量对载药微球释药速率的影响。结果表明：成功制备了球形圆整、分散性好、平均粒径约为15μm的CH-PL微球，其最大载药量和包封率分别为5．1％和42．8％；CH—PL微球具有良好的缓释效果，释药过程符合Higuichi机制，且微球的释药速率随交联剂用量的增加而变慢。
英文摘要：
Ciprofloxacin hydrochloride loaded e-polylysine（CH-PL） microspheres were prepared by means of emul- sifted--chemical crosslinking method. Drug-loading microspheres were characterized via scanning electron microscope, Fourier transform infrared spectrometer and Zetasize Nano ZS measurement. The release speed of CH-PL microspheres was determined under 0. 1mol/L HC1 （pH= 1.2） condition and effects of dosage of crosslinker on drug release were examined. The results showed that CH-PL microspheres had good shape and dispersibility with the average particle size of about 15 btm, the drug loading and drug encapsulation efficiency of CH-PL microspheres were 5. 1% and 42. 8%, respectively. The sustained release was remarkable, the drug release profile could be described by Higuichi eqution and the drug release speed was decreased with the increase of dosage of crosslinker.
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