中文摘要：

目的 观察藏药四味黄芪散对慢性低氧损伤大鼠的影响。方法 将100只大鼠随机分为两组：低氧对照组和低氧药物组（海拔5 000 m）,每组再根据暴露低氧时间分为1、3、7、15、30天等5个亚组,每组10只。另设10只为常氧对照组,暴露于西宁大气环境（海拔2 260 m）不干预。低氧药物组予藏药四味黄芪散混悬液（0.1 g/100 g）灌胃,低氧对照组予生理盐水灌胃,每天1次,持续30天。分别于暴露低氧时间结束后检测肺动脉压（Ppa）、左右心室比值[RV/（LV＋S）]、血红蛋白（Hb）和红细胞压积（Hct）值。结果 与常氧对照组比较,低氧对照组大鼠Hb、Hct、Ppa和RV/（LV＋S）均升高（P〈0.01）,并随着暴露低氧时间的延长而逐渐升高;与低氧对照组比较,低氧药物组大鼠Hb、Hct、Ppa和RV/（LV＋S）水平降低（P〈0.01）,且低氧环境中,低氧药物组大鼠Hb、Hct、Ppa和RV/（LV＋S）平均增幅值亦较低。结论 藏药四味黄芪散能够预防慢性低氧对机体的损伤。

英文摘要：

Objective To observe the effect of Tibetan medicine-Siwei Huangqi Powder on chronic hypoxic injury to rats. Methods Totally 100 SD rats were randomly divided into two groups ： the hypoxic control group and the hypoxic medicine group （altitude of 5 000 m）, and then each group was divided into 5 subgroups according to the exposure time to hypoxia at 1,3, 7,15 and 30 days,10 in each group. As a normoxic control group of 10 SD rats were exposed to the atmospheric pressure of Xining （altitude of 2 260 m） without any medicinal intervention. Rats in the hypoxic medicine group were administered by gas- trogavage with Tibetan medicine-Siwei Huangqi Powder at daily does of 0.1 g/100 g, while normal saline so- lution was given by gastrogavage to rats in hypoxic control group. All medication lasted for 30 days. At the end of exposure time, pulmonary arterial pressure （Ppa）, left and right ventricular ratio E RV/（LV ＋S）], hemoglobin （Hb） and hematocrit （Hct） values were measured respectively. Results Compared with the normoxic control group, the average of Hb, Hct, Ppa and RV/（LV ＋S） were significantly increased in hypoxic control with a time-dependent manner （P 〈0.01 ）. Compared with the hypoxic control group, the average of Hb, Hct, Ppa and RV/（LV ＋ S） were significantly decreased in hypoxic medicine group （P 〈0.01 ）, the increasing of Hb, Hct leves, PPA and RV/（LV ＋ S） value were decreased. Conclusion The Tibetan medicine-Siwei Huangqi Powder can prevent the injuries produced by chronic hypoxia.