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中文摘要：
目的 系统评价基本药物制度的实施对基层医疗机构门诊处方费用的影响。方法 全面收集有关基本药物制度前后基层医疗机构门诊处方费用研究的相关文献,利用RevMan5.0进行meta分析。结果 合并效应值MD=-11.42,95%CI为（-15.47,-7.10）;亚组分析显示基本药物制度实施后,农村基层医疗机构门诊单张处方费用的MD=-10.56,95%CI为（-15.59,-5.53）;城市基层医疗机构门诊单张处方费用的MD=-14.01,95%CI为（-17.15,-7.38）,模型的稳定性较好。倒漏斗图显示文献的发表偏倚较小,可以认为结果较为可靠。结论 基本药物制度实施后,基层医疗机构的门诊处方费用降低,且在城市地区的效果较农村地区相对明显。卫生行政部门应在保持基本药物政策持续性的基础上采取综合措施,进一步降低门诊处方费用。
英文摘要：
Objective To systematic reviews the impact of essential medicine system for outpatient prescription charges in the primary medical organizations. Methods Studies about outpatient prescription charges in the primary medical organiza- tions before and after the implementation of essential medicine system were collected. The literature collected underwent a meta- analysis by RveMan5.0. Results The overall effect size MD = - 8.89,95 % CI. （ - 12.42, - 5.36 ）. Subgroup analysis showed that after the implementation of essential medicine system MD of grassroots medical institutions in rural was -6. 25,95% C1： （ - 11.9, - 0. 6） and that in urban was - 14. 01,95 % CI： （ - 23.29, - 4. 73 ）, this model was stable. The funnel plot indicated that the publication bias was on the small side. Conclusion The essential medicine system reduces the outpatient prescription charges in grassroots medical institutions and the effect in urban was obviously than in rural. Comprehensive measures should be taken besides maintaining continuity to reduce the prescription charges.
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