中文摘要：

目的：采用析因设计分析补气生血方剂对失血性血虚小鼠的补血作用,寻求其发挥最佳药效的方剂配伍。方法：将因素A补气药的12个水平：人参、西洋参、党参、太子参、黄芪、白术、山药、白扁豆、甘草、大枣、刺五加、灵芝与因素B补血药的6个水平：当归、熟地黄、何首乌、白芍、阿胶、龙眼肉,按12×6析因设计法组成72个补气生血方剂。小鼠眼眶放血0.5 mL/每只复制失血性血虚模型,测定造模后第1,4,7,10天小鼠外周血细胞值。选用RBC,HGB,HCT为指标,根据析因设计重复测量统计方法对所得数据进行分析。结果：不同时间点各补气生血方剂对RBC的作用差异有统计学意义（P〈0.01）。补气药与补血药之间不存在交互作用。补气药各水平对RBC,HGB,HCT的影响具有统计学意义（P〈0.01）,以黄芪效果最佳。补血药各水平都有升高RBC,HGB,HCT的作用,各水平之间的差异不具有统计学意义,以当归效果最佳。黄芪当归配伍补血作用与模型组有显著性差异。结论：补气药对补气生血方剂作用的影响大于补血药,黄芪当归为最佳药效配伍。 更多还原

英文摘要：

Objective：To find out the best prescription composition of reinforcing Qi and enriching blood by factorial design in hemorrhagic blood deficient mouse.Method：The factor A with 12 levels was composed with 12 of reinforcing Qi medicine,such as Ginseng Radix et Rhizoma,Panacis Quinquefolii Radix,Codonopsis Radix,Pseudostellariae Radix,Astragali Radix,Atractylodis Macrocephalae Rhizoma,Dioscoreas Rhizoma,Glycyrrhizae et Rhizoma Radix,Jujubae Fructus,Acanthopanacis Senticosi Radix et Rhizoma Seu Caulis,Ganoderma and factor B with 6 levels was composed with 6 of enriching blood medicine,such as Angelicae Sinensis Radix,Rehmanniae Radix,Pblygoni Multiflori Radix,Paeoniae Alba Radix,Corii Asini Colla,Longan.The medicines composed 72 prescriptions of reinforcing Qi and enriching blood according to 12 × 6 factorial design.The hemorrhagic blood deficient model of mouse was established with 0.5mL orbital bleeding.Peripheral blood cells were counted after 1,4,7,10 d of modeling.The repeated measures of factorial design were used to analyze the data.Result：There was no interaction between reinforcing Qi medicine and enriching blood medicine.The difference in effect of the prescriptions of reinforcing Qi and enriching blood on RBC was significant at different time points（P 〈 0.01）.The difference in effect of different levels of reinforcing Qi on RBC,HGB and HCT was significant（P 〈 0.01）,and the Astragali Radix was the best.The effect of enriching blood medicines on RBC,HGB and HCT was all significant,and Angelicae Sinensis Radix was the best.The composition of Astragali Radix and Angelicae Sinensis Radix showed significant effect of enriching blood.Conclusion：The influence of reinforcing Qi medicine on the prescriptions is more strong than that of the medicines of enriching blood.Composition of Astragali Radix with Angelicae Sinensis Radix appears to be the best compatibility for the efficacy.