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无机纳米材料及作为药物载体的抗氧化作用研究进展
  • ISSN号:1001-8255
  • 期刊名称:《中国医药工业杂志》
  • 时间:0
  • 分类:R277.5[医药卫生—中医学] R289.5[医药卫生—方剂学;医药卫生—中药学;医药卫生—中医学]
  • 作者机构:[1]浙江衢化医院中医科,浙江衢州324004, [2]重庆医科大学重庆市生物化学与分子药理学重点实验室,重庆400016
  • 相关基金:国家自然科学基金面上项目(81373870)
中文摘要:

目的观察中西医结合治疗老年女性泌尿系感染的临床疗效,以探讨对老年女性泌尿系感染的更好药物治疗方案,从而提高治疗效果。方法选取于2014年1—12月医院收治的100例老年女性泌尿系感染患者,分为观察组和对照组,每组50例。对照组患者根据药敏的试验结果应用抗菌药物治疗,1周为一疗程,观察组在此基础上加用滋肾方加味汤剂治疗,1周为一疗程。2周后对比2组的临床疗效、症状改善时间、对血清超敏C反应蛋白影响和住院时间。结果观察组的总有效率为98.0%,显著高于对照组(80.0%),差异具有统计学意义(Z=3.375,P〈0.01);观察组的尿频急和尿痛的缓解时间显著短于对照组,差异具有统计学意义(t=7.203,9.433,P〈0.01);观察组治疗后血清超敏C反应蛋白降低明显优于对照组,差异具有统计学意义(t=12.141,P〈0.01);观察组患者住院时间为(11.7±2.5)d,低于对照组的(16.2±2.8)d,差异具有统计学意义(P〈0.05)。结论老年女性泌尿系感染在常规抗菌药物治疗的基础上加用中医药,能显著提高疗效,且症状改善明显,并降低血清中炎性介质水平,缩短患者住院时间,值得临床进一步推广。

英文摘要:

Objective To explore the efficacy ofcombining traditional Chinese and western medicine in the treatment of urinary tract infection diseasein female patients,modify the dosage regime and improve the curative efficacy. Methods Total 100 cases of urinary tract infection disease in female senile patients in our hospital were randomly divided into observation group and control group with 50 cases in each group. The control group was received antibiotic treatment according to their drug susceptibility test results,and the observation group was given Traditional Chinese medicine based on the control group. The efficacy,symptoms improved time,CRP and length of stay in the two groups of patients were compared after two weeks treatment. Results The total effective rate in the observation group was 98. 0%,significantly higher than that in the control group( 80. 0%),the difference was statistically significant( Z = 3. 375,P〈0. 01); the relief time of Urinary frequency and urinary pain in observation group were significantly shorter than those of the control group,the difference was statistically significant t = 7. 203,9. 433,P〈0. 01); The level of serum CRP reduced obviously when compared with the control group,the difference was statistically significant( t = 12. 141,P〈0. 01); In the observation group after the treatment,the length of stay was( 11. 7 ± 2. 5) days,significantly less than that in the control group( 16. 2 ± 2. 8) days,the difference was statistically significant( P〈0. 05). Conclusion Combining traditional Chinese and western medicine for urinary tract infection diseasein female senile patients had significant effect and less length of stay,and can significantly reduce the serum levels of inflammatory mediators,which is worthy of clinical promotion and research.

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期刊信息
  • 《中国医药工业杂志》
  • 中国科技核心期刊
  • 主管单位:上海医药工业研究院
  • 主办单位:上海医药工业研究院 中国化学制药工业协会
  • 主编:
  • 地址:上海市北京西路1320号
  • 邮编:200040
  • 邮箱:cjph@pharmadl.com
  • 电话:021-62793151
  • 国际标准刊号:ISSN:1001-8255
  • 国内统一刊号:ISSN:31-1243/R
  • 邮发代号:4-205
  • 获奖情况:
  • 1994年国家医药管理局信息成果一等奖,1996年上海市优秀科技期刊二等奖,1997年全国优秀科技期刊三等奖,中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 美国国际药学文摘,美国化学文摘(网络版),美国生物科学数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),英国英国皇家化学学会文摘,中国北大核心期刊(2000版)
  • 被引量:20697