中文摘要：

非小细胞肺癌脑转移是影响非小细胞肺癌患者生存期及生存质量的重要因素。目前，传统治疗的发展、小分子靶向药物的广泛应用以及各种联合治疗方式的采用共同影响着脑转移患者的疗效及预后。对新治疗靶点的研究以及对现有治疗的认知功能保护措施的探索也愈加为临床所关注。本文就非小细胞肺癌脑转移临床及基础的相关问题和治疗策略进行简要的梳理。

英文摘要：

Brain metastasis is among the most common complications of non-small cell lung cancer （NSCLC） and may obviously influence the survival and quality of life in the NSCLC patients. Recently, the development in traditional treatments, the widely-used micro-molecular targeted drugs, and the combined treatment have improved the overall survival and the quality of life of these patients. In addition, the exploration of new therapeutic targets and cognitive function protective methods for current treatments also deserves at- tention. This review emphasizes the relevant clinical and basic problems and the therapeutic strategies in NSCLC with brain metastases.