中文摘要：

采用非平衡磁控溅射法制备了3种不同结构的TiO2薄膜,对所得TiO2薄膜运用碱处理方法进行表面处理,期望在材料表面获得羟基活性基团。运用X射线衍射（XRD）研究了薄膜的表面结构。利用傅里叶红外技术（FTIR）和X射线光电子能谱仪（XPS）等手段对活化处理前后样品表面的羟基基团进行检测,并对活化前后样品进行了内皮细胞培养和血小板黏附实验。结果表明,运用碱处理方法,可以在锐钛矿型以及金红石与锐钛矿的混晶结构TiO2薄膜表面形成活性羟基基团;相比于金红石型TiO2薄膜,混晶结构和锐钛矿型具有较好的羟基活化能力。生物相容性实验表明,碱活化处理后样品表面细胞生长数目多于活化前样品,血小板黏附数量少于活化前样品,表面活性基团的存在有利于提高TiO2薄膜材料的生物相容性。此外,影响TiO2薄膜表面生物活化性能的因素进行了初步探讨。

英文摘要：

In this paper,the Titanium oxide films （TiO2） with three kind of different crystal structure were synthesized by unbalanced magnetron sputtering system. The crystal structures of films were characterized by the X-ray diffraction （XRD）. The TiO2 film surface was then treated by alkali solution to obtain hydroxyl functional group. The hydroxyl functional group was detected by fourier transform infrared spectrometer （FTIR） and Xray photoelectron spectroscopy （XPS） respectively. For evaluating the influence of surface hydroxyl functional group on cell compatibility and blood compatibility of the treated and untreated TiO2 films surface,the in vitro endothelial cell adhesion behavior and platelet adhesion were investigated respectively. The results showed that, compared to the rutile TiO2 film and the anatase TiO2 film,the TiO2 film mixed with anatase and rutile structure possesses the best hydroxyl activity ability. The endothelial cell and platelet adhesion investigation demonstrate that, compared to the untreated TiO2 films, the hydroxyl surface of treated TiO2 films has better cell compatibility and blood compatibility due to the more cultured endothelial cells and less adhered platelets onto its surface. This result indicates that the hydroxyl functional group can promote the growth and proliferation of endothelial cells and decrease the platelet adhesion. Furthermore,the work discusses the relationship between the TiO2 film structure and its hydroxyl ability.