中文摘要：

目的：研究以多腔压电泵驱动血液时对血细胞和凝血系统的影响。方法：建立体外模拟循环系统,以抗凝犬血为测试介质;压电泵驱动循环时间分为0、1和2h,并设立对照组;检测血液中血红蛋白浓度、白细胞、红细胞、血小板计数及红细胞比容,计算溶血指标（IH）。结果：与对照组比较,循环0h各指标差异无统计学意义（P〉0.05）;循环1和2h时,红细胞、白细胞、血小板计数、血红蛋白浓度及红细胞比容均降低（P〈0.05）。与对照组比较,循环1和2h时,游离血红蛋白浓度增高（P〈0.05）,纤维蛋白原浓度降低（P〈0.05）。但循环1h与2h比较,上述各指标差异无统计学意义（P〉0.05）。计算得到压电泵IH为0.004 5,明显低于国际标准溶血指标允许值0.1。结论：压电泵虽对血液成分和溶血有影响,但随循环时间延长该影响并不加重,IH在国际标准允许值范围内,表明其在体外实验中具有良好的血液相容性。

英文摘要：

Objective To explore the influence of multi-chamber piezoelectric pump on the blood cells and coagulation system when it applied as blood driving pump. Methods Anticoagulation dog blood was utilized as circulating medium in the simulative circulatory system. There were three groups depended on the circulation time （0, 1 and 2 h） and a control group. Hemoglobin concentration, white blood cell, red blood cell and platelet counts, hematocrit, free hemoglobin concentration were detected. The index of hemolysis （IH） of multi-chamber piezoelectric pump was calculated as an important index of hemolysis damage. Results Compared with control group, each index was not significantly changed in cycle 0 h group（P~0.05）. Compared with control group, the red blood cell count, white blood cell count, platelet count, hemoglobin concentration, hematocrit were decreased in cycle 1 h and 2 h groups（P〈0.05）. Compared with control group, the free hemoglobin concentration was increased, the fibrinogen concentration was decreased（P〈0.05）. Compared with cycle 1 h group, each index was not significantly changed in cycle 2 h group（P〈0.05）. The IH of pump was calculated as 0. 004 5, and it was significantly lower than international standard （〈 0.1）. Conclusion Multi-chamber piezoelectric pump has goodblood compatibility in vitro. It has advantages to apply as blood-driving pump.