中文摘要：

基于邻位叔丁基二甲基硅氧基（OTBS）手性基团诱导的亚胺（R，SRS）-8与甲基溴化镁高选择性加成环合串联反应制备4-OTBS-5-甲基吡咯酰胺1的新方法，经叠氮化与缩合等7步反应，以17%的总收率建立了抗精神病药（2S，3S）-奈莫必利选择性合成方法.

英文摘要：

An efficient method for the preparation of （4S,5R）-4-（tert-butyldimethylsilyloxy）-5-methylpyrrolidin-2-one （1） by an addition-cyclization-deprotection process of the imine （R,SRS）-8 with Grignard reagent is described. （2S,3S）-Nemonapride, a commercial antipsychotics, was asymmetrically synthesized by a concise and effective route involving above one-pot intramo-lecular tandem protocol in 17% overall yield from 8.