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兔眼房水引流至不同部位的降眼压效果
  • ISSN号:1004-7220
  • 期刊名称:医用生物力学
  • 时间:2013
  • 页码:554-558
  • 分类:R318.01[医药卫生—生物医学工程;医药卫生—基础医学]
  • 作者机构:[1]首都医科大学生物医学工程学院,北京100069, [2]首都医科大学宣武医院信息技术科,北京100053, [3]首都医科大学附属北京同仁医院眼科,北京100730
  • 相关基金:国家自然科学基金资助项目(31070840),北京市属市管高等学校人才强教深化计划项目高层次人才项目(PHR201110506),首都医科大学基础临床合作课题重点项目(12JL03).
  • 相关项目:眼后节房水流动对高眼压调控作用的动物实验研究
中文摘要:

目的观察并比较3种途径(引流至角膜缘、赤道部及眼后节)植入医用硅胶管降眼压的效果。方法选择健康新西兰白兔45只,单眼植入医用硅胶管将房水引流。根据植入途径分为角膜缘组、赤道部组和眼后节组,每组15只。结果对各实验组术前、术后眼压值进行统计对比,术后4周内眼后节组降眼压幅度最大(26.6%),赤道部组次之(16.2%),角膜缘组最小(1.2%);术后1、2和4周,赤道部组、角膜缘组、眼后节组的术前、术后眼压值比较差异均有统计学意义(P〈0.01);术后4周,眼后节组眼压下降幅度最大,且各组间眼压值差异均有统计学意义(P〈0.01)。结论将房水引流至眼后节时眼压下降幅度大,可为临床手术提供参考。

英文摘要:

Objective To observe and compare the effects of intraocular pressure (lOP) drop when the aqueous humor was drained to limbus, ambitus and posterior segment of rabbit eye by implanting medical silicone tube. Methods Forty-five healthy New Zealand white rabbits were chosen for the experimental group, each with the medical silicone tube implanted in one eye. According to different implanting ways, the rabbits were divided into the limbus group, ambitus group and posterior segment group respectively, with 15 rabbits in each group. Results According to statistical comparison of preoperative and postoperative lOP values among the 3 groups within 4 weeks, the lOP of the posterior segment group was decreased most by 26.6%, and that of the ambitus group and limbal group was decreased by 16.2% and 1.2%, respectively. The differences between the preoperative and postoperative lOP in first, second and fourth week were statistically significant (P 〈 0.01 ) for all three groups. The lOP of the posterior segment group after 4 weeks was decreased most, and there were significant differences in lOP values among three groups ( P 〈 0.01). Conclusions The greatest lOP drop occurred when the aqueous humor was drained to the posterior segment of the rabbit eye, and this result could provide some ref- erence for the clinical surgery.

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期刊信息
  • 《医用生物力学》
  • 北大核心期刊(2011版)
  • 主管单位:教育部
  • 主办单位:上海交通大学
  • 主编:戴尅戎
  • 地址:上海市制造局路639号
  • 邮编:200011
  • 邮箱:shengwulixue@163.com
  • 电话:021-53315397
  • 国际标准刊号:ISSN:1004-7220
  • 国内统一刊号:ISSN:31-1624/R
  • 邮发代号:4-633
  • 获奖情况:
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,荷兰文摘与引文数据库,美国剑桥科学文摘,中国中国科技核心期刊,中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:4565