中文摘要：

3-氰甲基吲哚酮是一类重要的药物合成中间体，利用其氰基官能团的转化可以合成Horsfiline、Esermethole和Physostigmine等天然产物．发展了一种水溶液中的Heck／氰基化串联反应，可以绿色、简便地合成3-氰甲基吲哚酮类化合物，该方法与文献方法相比，不仅能够以绿色介质水代替有机溶剂，而且不需要添加碱作为缚酸剂，为3-氰甲基吲哚酮类化合物提供了一种绿色高效的合成新途径．

英文摘要：

3-Cyanomethyl oxoindoles are a kind of important drug intermediates, which can be used to synthesize horsfiline, esermethole and physostigmine and other natural products via the conversion of cyano functional groups. A domino Heck/cyanation reaction in aqueous was developed to afford 3-cyanomethyl oxoindole compounds. This method, using green medium water instead of organic solvents, without any basic additives, provided a green and efficient new procedure for the synthesis of 3-cyanomethyl oxoindoles.