中文摘要：

应用常规电生理学细胞外记录技术，研究了生后3周龄幼年大鼠皮层听-视双模态神经元及听-视信息整合特性，并与成年动物进行对照。在听皮层的背侧，听皮层和视皮层的交界处，即颞-顶-枕联合皮层区，共记录到了324个神经元，其中45个为听-视双模态神经元，占13．9％，远低于成年动物双模态神经元所占比例（42．8％）。这些双模态神经元可分为A—V型，v-A型和a-V型3种类型。根据它们对听-视信息的整合效应，可分为增强型、抑制型和调制型。整合效应与给予的声和光组合刺激的时间间隔有关，以获得整合效应的时间间隔范围为整合时间窗，幼年动物的平均整合时间窗为11．9ms，远小于成年动物的整合时间窗（平均为23．2ms）。结果提示，与单模态感觉神经元对模态特异性反应特性一样，皮层听-视双模态神经元生后有一个发育、成熟的过程。研究结果为深入研究中枢神经元多感觉整合机制提供了重要实验资料。

英文摘要：

Conventional extracellular recording electrophysiology techniques were applied to study the auditory-visual multisensory neurons and the characteristics of auditory-visual information integration in 3-week-old newborn rat cortex. At the boundary area between the auditory and visual cortex, that is the temporal-parietal- occipital associated cortex, a total of 324 neurons were recorded, of which 45 were auditory-visual bimodal neurons. Newborn bimodal neurons were only 13.9% of the total,and this percentage was much lower than that in the adult animals （42.8%）. According to their different responses to auditory-visual stimuli, these bimodal neurons were divided into three types： A-V, v-A and a-V neurons. However, neurons could be categorized into response enhancement type, response depression type and response modulation type according to their auditory-visual information integration capacity. Integration effect was related to the interstimulus interval of the combination of auditory and visual stimuli, and to the temporal window within which significant auditory-visual integration were generated. The mean temporal window of newborn rats is 11.9 ms, much shorter than that of adult ones （23.2 ms on average）. All these results indicate that auditory-visual bimodal neurons, like those unimodal neurons specifically responding to certain modal stimuli, go through a developmental maturation course after birth. This work could provide important experimental data for further study on the mechanism of neural multisensery integration.