中文摘要：

14-3-3蛋白家族在真核细胞中广泛表达且高度保守,据报道其与心血管疾病、神经元损伤、帕金森病以及支气管哮喘等疾病有关联,近年来研究发现14-3-3蛋白与癌症的发生和发展也密切相关,而涉及的癌症包括胆管癌、肝癌、肺癌、鼻咽癌、口腔癌、食管癌、胃癌、乳腺癌、卡波济肉瘤、脑膜癌、直肠癌、星形细胞瘤等几乎所有常见癌症。14-3-3蛋白对癌症增殖、转移、凋亡以及耐药等影响作用已经得到证实,其调控机制也得到部分揭示,并且已合成了影响14-3-3蛋白与其他蛋白相互作用的特异小分子阻断药物。人体内的14-3-3蛋白家族包含β,ε,γ,η,θ（τ）,ζ和σ7种亚型,不同亚型有不同的组织定位和功能。阐明各亚型在不同肿瘤中的分布、作用及其调控机制,对我们进一步认识和治疗癌症均有一定的指导意义。

英文摘要：

The 14-3-3 protein family in eukaryotic cells is widely expressed and highly conservative.It was reported that 14-3-3 proteins were associated with the cardiovascular and cerebrovascular diseases,neuron protection,Parkinson＇s disease,bronchial asthma,and so on.In recent years,more and more studies focus on the relationship between 14-3-3 proteins and cancers.14-3-3 Proteins were involved in multiple common cancers such as liver cancer,lung cancer,nasopharyngeal carcinoma,esophageal cancer,gastric cancer,breast cancer,colorectal cancer,etc.The effects of 14-3-3 proteins on proliferation,metastasis,apoptosis,and resistance of cancer cells had been confirmed and a part of mechanisms had been elucidated.The family of mammalian 14-3-3 protein has 7 isoforms：β,ε,γ,η,θ,τ and ζ（σ）.Different 14-3-3 isoforms display different tissue localization and function.In this article,the activities of 14-3-3 isoforms in different tumor cells were summarized.The possible regulatory mechanisms of 14-3-3 in cancer were discussed.Clarification of the tissue distribution and function of 14-3-3 isoforms may help us to explore a new effective approach for cancer therapy.