中文摘要：

细胞的老朽是响应象 telomere 机能障碍和 DNA 损坏一样的各种各样的外长、内长的刺激的一个不可逆的房间周期拘捕节目。它广泛地作为一个反肿瘤节目被接受了并且也与胚胎开发，织物修理， organismal 老化和年龄相关的退化疾病有关仔细被发现。在过去的十年，众多的努力被作了揭开基因细胞的老朽的规章的机制。有一个强壮的要求从各种各样的资源把这些数据集成到一个开的平台。在细胞的老朽上便于研究人员，我们由把多重在网上出版的数据来源集成到一个全面老朽基因注解平台(http://bioinfo.au.tsinghua.edu.cn/member/xwwang/HCSGD ) 开发了人的细胞的老朽基因数据库(HCSGD ) 。潜在的人的细胞的老朽基因(HCSGS ) 被从出版文学，基因表示介绍数据和蛋白质蛋白质相互作用网络联合信息收集。另外，基因与基因本体论注解和 microRNA/drug/compound 目标信息被注解。HCSGD 提供一个珍贵资源设想细胞的老朽基因网络，浏览注解功能的信息，并且检索有一个用户友好的网接口的联系老朽的基因。

英文摘要：

Cellular senescence is an irreversible cell cycle arrest program in response to various exogenous and endogenous stimuli like telomere dysfunction and DNA damage.It has been widely accepted as an antitumor program and is also found closely related to embryo development,tissue repair,organismal aging and age-related degenerative diseases.In the past decades,numerous efforts have been made to uncover the gene regulatory mechanisms of cellular senescence.There is a strong demand to integrate these data from various resources into one open platform.To facilitate researchers on cellular senescence,we have developed Human Cellular Senescence Gene Database（HCSGD） by integrating multiple online published data sources into a comprehensive senescence gene annotation platform（http：//bioinfo.au.tsinghua.edu.cn/member/xwwang/HCSGD）.Potential Human Cellular Senescence Genes（HCSGS）were collected by combining information from published literatures,gene expression profiling data and Protein-Protein Interaction networks.Additionally,genes are annotated with gene ontology annotation and microRNA/drug/compound target information.HCSGD provides a valuable resource to visualize cellular senescence gene networks,browse annotated functional information,and retrieve senescenceassociated genes with a user-friendly web interface.