中文摘要：

目的探讨单次给予小鼠乙醇灌胃对其丙泊酚麻醉效果及麻醉后氧化应激指标的影响。方法 40只昆明小鼠随机分为4组：0.9%氯化钠注射液灌胃组（NS组）,0.9%氯化钠注射液灌胃＋丙泊酚80 mg/kg组（PPF组）,50%无水乙醇6ml/kg灌胃＋0.9%氯化钠注射液腹腔注射组（Alcohol组）及50%无水乙醇6 ml/kg灌胃＋丙泊酚80 mg/kg组（Alcohol＋PPF组）。小鼠0.9%氯化钠注射液或乙醇灌胃10 min后给予丙泊酚或0.9%氯化钠注射液腹腔注射,观察并记录小鼠麻醉诱导时间及维持时间,待小鼠翻正反射恢复后统一眼球取血,测定各组小鼠血清中SOD活性及MDA含量。结果与PPF组相比,Alcohol＋PPF组麻醉诱导时间缩短[（3.19±0.48）min vs（1.43±0.19）min]（P〈0.01）,麻醉维持时间延长[（67.01±6.46）min vs（183.41±12.60）min]（P〈0.01）;与NS组[（38.50±6.02）U/ml]相比,Alcohol组[（33.09±3.81）U/ml]（P〈0.05）、PPF组[（33.91±4.62）U/ml]（P〈0.05）、Alcohol＋PPF组[（30.98±3.51）U/ml]（P〈0.01）SOD活性均降低;与NS组[（5.21±0.92）nmol/ml]相比,Alcohol组[（9.16±1.85）nmol/ml]、PPF组[（9.37±1.52）nmol/ml]及Alcohol＋PPF组[（10.14±1.76）nmol/ml]MDA含量均升高（P均〈0.01）。结论乙醇可使小鼠麻醉诱导时间缩短、麻醉维持时间延长,并使小鼠血清SOD活性降低,过氧化反应中的代谢产物丙二醛增多,对临床醉酒患者的麻醉用药有一定参考意义。

英文摘要：

Objective To explore the effects of intragastric administration of alcohol on anesthesia effect and antioxidant activity in mice with propofol anesthesia. Methods Forty mice were divided into intragastric administration of saline group（NS group）, intragastric administration of saline and propofol 80 mg/kg group（PPF group）, intragastric administration of 50% absolute ethanol 6 ml/kg and intraperitoneal injection with saline group（Alcohol group）, intragastric administration of 50% absolute ethanol 6 ml/kg and propofol 80 mg/kg group（Alcohol＋ PPF group） with 10 in each group. The mice were anaesthetized by intraperitoneal injection with saline or propofol at 10 minutes after administration of alcohol or 0.9% saline. The anesthesia induction and maintenance were observed and recorded. The SOD and MDA in serum of all groups were measured after righting reflex recovered. Results Compared with PPF group, the induction time of Alcohol＋ PPF group was shorter and maintenance phase of Alcohol＋ PPF group was longer with significant differences [（3.19±0.48） min vs（1.43±0.19） min,（67.01±6.46） min vs（183.41±12.60） min, P〈0.01]; Compared with NS group, the SOD level in serum of Alcohol group, PPF group and Alcohol＋ PPF group decreased significantly [（38.50±6.02） U/ml vs（33.09±3.81） U/ml,（33.91±4.62） U/ml,（30.98±3.51）U/ml, P 0.01]; Compared with NS group, the MDA level in serum of Alcohol group, PPF group and Alcohol＋ PPF group increased significantly [（5.21±0.92） nmol/ml vs（9.16±1.85） nmol/ml,（9.37±1.52） nmol/ml,（10.14±1.76） nmol/ml, P 0.05]. Conclusion Alcohol can reduce anesthesia induction time, prolong maintenance phase, decrease the activity of serum SOD and increase the level of MDA in mice with propofol, which has important clinical significance to anesthetic selection for alcoholics.