中文摘要：

设计合成了2种含炔基的甘露糖衍生物（A—Man和A—DiMan）及2-[2-（2-叠氮乙氧基）-乙氧基]．乙胺（N3-TEG-NH2）．以N3-TEG—NH2为引发剂引发N8-苄氧羰基-L-赖氨酸酸酐（Lys（z）-NCA）的开环聚合，得到2种分子量不同的端基含叠氮基团的聚赖氨酸，N3-P（Lys（z））15和N3-P（Lys（Z））。分别与A—Man和A-DiMan进行点击化学反应得到4种端基含甘露糖的聚合物．用透射电镜研究了4种聚合物在水溶液中的聚集行为，结果表明，基于P（Lys（z））15的2种糖聚合物聚集形成囊泡，而基于P（Lys（Z））35的2种糖聚合物则聚集形成胶束．

英文摘要：

Two alkynyl-functionalized mannoses （A-Man and A-DiMan） and 2-（2-（2-azido-ethoxy）-ethoxy）- ethyl amine （N3-TEG-NH2 ） were synthesized. N3-TEG-NH2 was used to initiate the ring-opening polymerization of N6-benzyloxyearbonyl-L-lysine N-carboxyanhydride （Lys （Z）-NCA） to obtain two azidoterminated polylysines with different degree of polymerization, N3-P （ Lys （Z） ） 15 and N3-P （ Lys （Z） ） 3 5- Click reactions of these two polymers with A-Man and A-DiMan produced four mannose-terminated polylysines, M- P（ Lys（Z） ） 15, M-P（ Lys（Z） ） 35, DiM-P（ Lys（Z） ） 15 and DiM-P（ Lys（Z） ） 35. The structure of these polymers was characterized by a range of means including GPC, NMR and FTIR. These polymers belong to amphiphilic diblock copolymers with P （ Lys （Z） ） as the hydrophobic chain and the mannose-containing moieties as the hydrophilie part,and their aggregation behavior in water were investigated. The polymers were first dissolved in THF/DMF （4/1, V/F） , and then water was added slowly to induce the self-assembly of polymers. After removing the orgnic solvents by dialysis, the morphologies formed were observed by transmission electron microscopy （TEM）. TEM results revealed that vesicles were the main morphologies for the two polymers with shorter P（ Lys（ Z ）） chains （M-P （Lys （Z））15 and DiM-P（ Lys （Z））15 ）, while the two polymers with longer P （ Lys （Z） ） chains （ M-P （ Lys （Z） ） 35 and DiM-P （ Lys （Z） ） 35 ） tended to form micelle-like aggregates. This phenomenon was different from the common self-assembly behavior of amphiphilic diblock copolymers in water,which was attributed to the easy a-helix formation of polymers containing longer P（Lys（Z）） chains.