中文摘要：

DNA损伤是细胞最常见的损伤，DNA修复蛋白可以对DNA损伤进行修复，在维持生物体基因组的完整性和抑制肿瘤的发生中起着重要的作用。DNA损伤修复基因表达的正常与否与肿瘤的进展有关。该文对目前的研究热点——人类X射线交叉互补修复基因（XRCC）家族中XRCCl、XRCC2和Rad51基因多态性与肿瘤的关系进行了综述。

英文摘要：

DNA repair protein can repair DNA damage of cells and play important roles in maintaining the integrity of the genetic information and suppressing the formation of tumor. The expression of DNA repair genes associates with the development of tumors. In this review, an overview of the relationship between XRCC 1, XRCC2 and Rad51 polymorphism of X-ray repair cross complementing gene family and tumors was introduced.