中文摘要：

目的总结新生儿MN血型不合溶血病的临床特点、诊治经验及发病机理。方法报告我科近年诊治的3例新生儿MN血型不合溶血病，复习我科曾报道的另外2例，并通过中国知网、万方数据库和维普中文期刊数据库，检索国内近24年来报告的所有病例报告，对患儿的临床表现和实验室检查进行总结分析。结果包括本文报道的3例，国内共报道31例新生儿MN血型不合溶血病，MN型25例，M型6例；直接抗人球蛋白试验阳性13例，抗体释放试验阳性17例，患儿血型抗体IgG抗M型阳性28例；母亲血型抗体IgG抗M型阳性30例，IgM抗M阳性16例。31例患儿中6例（19．4％）为第1胎发病，贫血发生率67．7％，其中重度贫血发生率29．0％，重度高胆红素血症发生率22．6％；较多患儿需要换血（29．0％）和输血（45．2％）；病死率9．7％。结论新生儿MN血型不合溶血病容易出现黄疸、贫血，可导致患儿急性死亡。光疗、输注丙种球蛋白、白蛋白等治疗效果良好，严重病例需要换血、输血治疗。为了提高MN溶血病的诊断率，应检测孕妇MN血型及抗M抗体效价。

英文摘要：

Objective To review the clinical manifestations, diagnosis and treatments of hemolytic disease of the newborn （HDN） due to anti-M. Methods In order to summarise the clinical features of HDN and relevant diagnostic tests, data was collected including 5 cases of HDN due to anti-M from our ward （ including 2 cases reported previously） as well as eases recorded in the CNKI, Wan Fang, and Wei Pu clinical databases. Results There were 26 cases of HDN due to anti M collected from the clinical databases, which covered almost all the published Chinese literature for the past 24- years. Of the 31 cases, 25 had MN blood group, 6 had M blood group, 13 had positive direct antiglobin, 17 had positive antibody release test, IgG anti M was positive in 28 infants. There were 30 mothers who were positive for IgG anti M and 16 mothers were positive for lgM anti M. 19.4% of mothers were G1P1, there was high incidence of anemia （severe anemia was 29.03% with total anemia 67.7% ）, The incidence of severe hyperbilirubinemia was 22.6% , 29.0% patients needed exchange transfusion, and 45.2% needed blood transfusion, 3 infants （9.7%） died. Conclusions HDN due to anti-M can cause severe pathological jaundice and anemia in newborn infants. Phototherapy, intravenous infusions of IVIG and albumin are routine treatments, severe cases needed exchange transfusion and/or blood transfusion. Detection of MN blood type and the concentration of anti M of pregnant mothers will improve diagnosis of HDN due to anti-M.