中文摘要：

化疗是晚期肿瘤患者综合序列治疗的重要组成部分,但肿瘤细胞的耐药性常导致临床化疗失败。肿瘤干细胞能驱动肿瘤生成,如果化疗药物不能有效靶向作用于肿瘤干细胞,即使肿瘤缩小,残存的肿瘤干细胞也会迅速驱动肿瘤的复发。本文主要总结近年来关于肿瘤干细胞参与化疗耐药可能分子机制的研究成果,和靶向使肿瘤干细胞对治疗敏感性增加的新方法。

英文摘要：

Chemotherapy is an indispensable component of systemic therapy on patients with advanced malignancies, yet the outcome is not always success due to the drug resistance of cancer cells. Cancer stem cells are a subpopulation of tumor cells that can initiate tumor formation. If chemotherapy kills bulk of cells within a tumor but not cancer stem cells,the surviving cancer stem cells can initiate the formation of recurrent tumors. This article discusses recent progresses related to cancer stem cell and drug resistance. Approaches to target cancer stem cells to improve the efficacy of chemotherapy will also be discussed.