中文摘要：

以巯基乙酸为稳定剂,直接合成了水溶性CdTe量子点。基于尼群地平对合成量子点的荧光猝灭效应,建立了一种简便、快速和灵敏地测定尼群地平的分析方法。考察了缓冲体系、缓冲液浓度、缓冲液pH值、反应时间、量子点浓度对尼群地平测定的影响,在0.03 mol/L、pH值为8.3的Tris-HCl缓冲液中,当量子点的浓度为6.0×10^-4mol/L、反应时间为5 min,体系的相对荧光强度与尼群地平的质量浓度呈良好线性关系,其线性范围为1.09-65.4 mg/L,线性系数为0.998 6,检出限（S/N=3）为0.11 mg/L。该方法已成功用于药片中尼群地平的测定,与中国药典中的标准方法比较,结果满意。同时该文对尼群地平与CdTe量子点的反应机理进行了初步探讨。

英文摘要：

Water-soluble CdTe quantum dots were synthesized in aqueous solution with thioglycolic acid as stabilizer.Based on the quenching of the fluorescence intensity of functionalized CdTe quantum dots（QDs） by nitrendipine,a simple,rapid and sensitive method for the determination of nitrendipine was proposed and validated.The effects of experimental conditions,including the type and pH of buffer,reacting time,concentration of CdTe QDs,on the determination of nitrendipine were investigated in detail.The optimal conditions were as the follows：buffer：pH 8.3 0.03 mol/L Tris-HCl,concentration of quantum dots：6.0×10-4 mol/L,reacting time：5 min.Under the optimal conditions,a good linearity（r=0.998 6） was obtained between fluorescence intensity and nitrendipine concentration in the range of 1.09-65.4 mg·L-1.The limit of detection（3δ） was 0.11 mg·L-1.The contents of nitrendipine in pharmaceutical tablets were successfully determined by the proposed method,and the results were in good agreement with that of the national standard method in Chinese Pharmacopoeia.Forthermore,the possible mechanism of interaction between CdTe QDs and nitrendipine was discussed.